HtrA - Revision history

Jstuelk: /* Reviews */

2014-09-19T10:43:24Z

‎Reviews

134.76.70.252 at 09:59, 17 April 2014

2014-04-17T09:59:12Z

134.76.38.147 at 13:30, 2 April 2014

2014-04-02T13:30:15Z

Jstuelk: /* Original publications */

2014-02-20T17:02:05Z

‎Original publications

Jstuelk at 16:57, 20 February 2014

2014-02-20T16:57:03Z

Jstuelk at 16:35, 16 January 2014

2014-01-16T16:35:18Z

Jstuelk at 16:29, 16 January 2014

2014-01-16T16:29:57Z

Jstuelk at 17:21, 15 January 2014

2014-01-15T17:21:24Z

134.76.70.252 at 10:35, 7 January 2014

2014-01-07T10:35:39Z

Jstuelk: /* Reviews */

2013-12-03T09:33:50Z

‎Reviews

← Older revision		Revision as of 10:43, 19 September 2014
Line 1:		Line 1:
−	* '''Description:''' membrane-anchored protein quality control protease, serine protease Do <br/><br/>	+	{{#bank: HtrA}}
−	{~~\| align="right" border="1" cellpadding="2"~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\|'''Gene name'''~~
−	~~\|''htrA''~~
−	\|-
−	~~\|style="background:~~#~~ABCDEF;" align="center"\| '''Synonyms''' \|\| ''ykdA ''~~
−	\|-
−	~~\|style="background~~:~~#ABCDEF;" align="center"\| '''Essential''' \|\| no~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Product''' \|\| serine protease Do~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\|'''Function''' \|\| protein quality control~~
−	\|-
−	\|colspan="2" style="background:#FAF8CC;" align="center"\| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU12900 htrA]
−	\|-
−	\|colspan="2" style="background:#FAF8CC;" align="center"\| '''Metabolic function and regulation of this protein in [[SubtiPathways\|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=htrA htrA]'''
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''MW, pI''' \|\| 47 kDa, 4.699~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Gene length, protein length''' \|\| 1347 bp, 449 aa~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\|'''Immediate neighbours''' \|\| ''[[ykcC]]'', ''[[proG]]''~~
−	\|-
−	\|style="background:#FAF8CC;" align="center"\|'''Sequences'''\|\|[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU12900 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU12900 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU12900 DNA_with_flanks]
−	\|-
−	\|-
−	\|-
−	~~\|colspan="2" \| '''Genetic context''' <br/> [[Image:htrA_context.gif]]~~
−	~~<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>~~
−	\|-
−	~~\|colspan="2" \|'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=htrA_1357936_1359285_-1 Expression at a glance]'''   {{PubMed\|22383849~~}~~}<br/>[[Image:htrA_expression.png\|500px\|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU12900]]~~
−	\|-
−	\|}

−	~~__TOC__~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/>~~
−
−	~~= [[Categories]] containing this gene/protein =~~
−	~~{{SubtiWiki category\|[[proteolysis]]}},~~
−	~~{{SubtiWiki category\|[[heat shock proteins]]}},~~
−	~~{{SubtiWiki category\|[[membrane proteins]]}}~~
−
−	~~= This gene is a member of the following [[regulons]] =~~
−	~~{{SubtiWiki regulon\|[[CssR regulon]]}}~~
−
−	~~=The gene=~~
−
−	~~=== Basic information ===~~
−
−	* '''Locus tag:''' BSU12900
−
−	~~===Phenotypes of a mutant ===~~
−
−	~~=== Database entries ===~~
−	* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU12900&redirect=T BSU12900]
−
−	* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/htrA.html]
−
−	* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG12608]
−
−	~~=== Additional information===~~
−
−
−	~~=The protein=~~
−
−	~~=== Basic information/ Evolution ===~~
−
−	* '''Catalyzed reaction/ biological activity:'''
−	** required for folding of the secreted protein [[YqxI]] {{PubMed\|23937099}}
−
−	* '''Protein family:''' PDZ (DHR) domain (according to Swiss-Prot)
−
−	* '''Paralogous protein(s):''' [[HtrC]]
−
−	~~=== Extended information on the protein ===~~
−
−	* '''Kinetic information:'''
−
−	* '''[[Domains]]:'''
−
−	* '''Modification:'''
−
−	* '''[[Cofactors]]:'''
−
−	* '''Effectors of protein activity:'''
−
−	* '''[[SubtInteract\|Interactions]]:'''
−
−	* '''[[Localization]]:'''
−	** cell membrane (according to Swiss-Prot)
−	** extracellular (signal peptide) [http://www.ncbi.nlm.nih.gov/pubmed/18957862 PubMed]
−	** randomly distributed in foci throughout the cell surface {{PubMed\|22307758}}
−
−	~~=== Database entries ===~~
−	* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU12900&redirect=T BSU12900]
−
−	* '''Structure:'''
−
−	* '''UniProt:''' [http://www.uniprot.org/uniprot/O34358 O34358]
−
−	* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU12900]
−
−	* '''E.C. number:'''
−
−	~~=== Additional information===~~
−
−	~~=Expression and regulation=~~
−
−	* '''Operon:''' ''htrA'' (according to [http://dbtbs.hgc.jp/COG/prom/htrA.html DBTBS])
−
−	* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=htrA_1357936_1359285_-1 htrA] {{PubMed\|22383849}}
−
−	* '''[[Sigma factor]]:''' [[SigA]] {{PubMed\|10692364}}
−
−	* '''Regulation:'''
−	** expressed under conditions of secretion stress ([[CssR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/11555295 PubMed]
−	** induced by rhamnolipids {{PubMed\|22092710}}
−
−	* '''Regulatory mechanism:'''
−	** [[CssR]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/11555295 PubMed]
−
−	* '''Additional information:'''
−	** [[HtrA]] is subject to degradation by [[WprA]] and other extracellular proteases {{PubMed\|24362423}}
−	** number of protein molecules per cell (minimal medium with glucose and ammonium): 91 {{PubMed\|24696501}}
−
−	~~=Biological materials =~~
−
−	* '''Mutant:'''
−	** 1A933 (no resistance), {{PubMed\|10692364}}, available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A933&Search=1A933 BGSC]
−
−	* '''Expression vector:'''
−
−	* '''lacZ fusion:'''
−
−	* '''GFP fusion:'''
−
−	* '''two-hybrid system:'''
−
−	* '''Antibody:'''
−
−	~~=Labs working on this gene/protein=~~
−
−	~~=Your additional remarks=~~
−
−	~~=References=~~
−	~~==Reviews==~~
−	~~<pubmed>22688815 21326199 </pubmed>~~
−
−	~~== Original publications ==~~
−	~~<pubmed>17600057,12270824 ,11555295,18957862, 10692364 21624103 22307758 22092710 24362423 23937099 24115457 11133960 </pubmed>~~
−	~~[[Category:Protein-coding genes]]~~

@@ Line 126: / Line 126: @@
 * '''Additional information:'''
 ** [[HtrA]] is subject to degradation by [[WprA]] and other extracellular proteases {{PubMed|24362423}}
 =Biological materials =

@@ Line 57: / Line 57: @@
 === Database entries ===
 * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/htrA.html]
@@ Line 96: / Line 97: @@
 === Database entries ===
 * '''Structure:'''

@@ Line 149: / Line 149: @@
 == Original publications ==
-<pubmed>17600057,12270824 ,11555295,18957862, 10692364 21624103 22307758 22092710 24362423 23937099 24115457 </pubmed>
+<pubmed>17600057,12270824 ,11555295,18957862, 10692364 21624103 22307758 22092710 24362423 23937099 24115457 11133960 </pubmed>
 [[Category:Protein-coding genes]]

@@ Line 149: / Line 149: @@
 == Original publications ==
-<pubmed>17600057,12270824 ,11555295,18957862, 10692364 21624103 22307758 22092710 24362423 23937099</pubmed>
+<pubmed>17600057,12270824 ,11555295,18957862, 10692364 21624103 22307758 22092710 24362423 23937099 24115457 </pubmed>
 [[Category:Protein-coding genes]]

@@ Line 70: / Line 70: @@
 * '''Catalyzed reaction/ biological activity:'''
 * '''Protein family:''' PDZ (DHR) domain (according to Swiss-Prot)
@@ Line 148: / Line 149: @@
 == Original publications ==
-<pubmed>17600057,12270824 ,11555295,18957862, 10692364 21624103 22307758 22092710 24362423</pubmed>
+<pubmed>17600057,12270824 ,11555295,18957862, 10692364 21624103 22307758 22092710 24362423 23937099</pubmed>
 [[Category:Protein-coding genes]]

@@ Line 79: / Line 79: @@
 * '''Kinetic information:'''
-* '''Domains:'''
+* '''[[Domains]]:'''
 * '''Modification:'''
-* '''Cofactor(s):'''
+* '''[[Cofactors]]:'''
 * '''Effectors of protein activity:'''
@@ Line 112: / Line 112: @@
 * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=htrA_1357936_1359285_-1 htrA] {{PubMed|22383849}}
-* '''Sigma factor:''' [[SigA]] {{PubMed|10692364}}
+* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|10692364}}
 * '''Regulation:'''
@@ Line 122: / Line 122: @@
 * '''Additional information:'''
 =Biological materials =
@@ Line 147: / Line 148: @@
 == Original publications ==
-<pubmed>17600057,12270824 ,11555295,18957862, 10692364 21624103 22307758 22092710</pubmed>
+<pubmed>17600057,12270824 ,11555295,18957862, 10692364 21624103 22307758 22092710 24362423</pubmed>
 [[Category:Protein-coding genes]]

@@ Line 38: / Line 38: @@
 <br/><br/><br/><br/>
 <br/><br/><br/><br/>
-<br/><br/><br/><br/><br/><br/>
+<br/><br/>
 = [[Categories]] containing this gene/protein =
@@ Line 73: / Line 73: @@
 * '''Protein family:''' PDZ (DHR) domain (according to Swiss-Prot)
-* '''Paralogous protein(s):''' [[YyxA]]
+* '''Paralogous protein(s):''' [[HtrC]]
 === Extended information on the protein ===

@@ Line 15: / Line 15: @@
 |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU12900 htrA]
 |-
-|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress], [http://subtiwiki.uni-goettingen.de/wiki/index.php/Protein_secretion Protein secretion]'''
+|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=htrA htrA]'''
 |-
 |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 47 kDa, 4.699

@@ Line 144: / Line 144: @@
 =References=
 ==Reviews==
-<pubmed>22688815 </pubmed>
+<pubmed>22688815 21326199 </pubmed>
 == Original publications ==
 <pubmed>17600057,12270824 ,11555295,18957862, 10692364 21624103 22307758 22092710</pubmed>
 [[Category:Protein-coding genes]]