FtsX - Revision history

134.76.70.252 at 10:08, 17 April 2014

2014-04-17T10:08:05Z

134.76.38.147 at 14:55, 2 April 2014

2014-04-02T14:55:09Z

Jstuelk at 19:35, 14 December 2013

2013-12-14T19:35:20Z

134.76.70.252 at 09:26, 12 November 2013

2013-11-12T09:26:53Z

Jstuelk at 16:54, 19 July 2013

2013-07-19T16:54:49Z

Jstuelk at 12:02, 16 July 2013

2013-07-16T12:02:50Z

134.76.70.252 at 14:41, 16 May 2013

2013-05-16T14:41:44Z

134.76.70.252 at 11:23, 14 May 2013

2013-05-14T11:23:47Z

134.76.70.252 at 13:58, 13 May 2013

2013-05-13T13:58:25Z

Jstuelk at 10:43, 10 May 2013

2013-05-10T10:43:27Z

← Older revision		Revision as of 10:08, 17 April 2014
Line 1:		Line 1:
−	* '''Description:~~''' [[ABC transporter]] (membrane protein) ([[FtsE]]-[[~~FtsX~~]]), required for [[CwlO]] activity (cell elongation) and for proper activation of [[Spo0A]] and initiation of [[sporulation]] <br/><br/>~~	+	{{#bank: FtsX}}

−	~~{\| align="right" border="1" cellpadding="2"~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\|'''Gene name'''~~
−	~~\|''ftsX''~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Synonyms''' \|\| '' ''~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Essential''' \|\| no~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Product''' \|\| [[ABC transporter]] (membrane protein)~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\|'''Function''' \|\| control of [[cell wall synthesis]]~~
−	\|-
−	\|colspan="2" style="background:#FAF8CC;" align="center"\| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU35250 ftsX]
−	\|-
−	\|colspan="2" style="background:#FAF8CC;" align="center"\| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=FtsX FtsX]
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''MW, pI''' \|\| 32 kDa, 10.016~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Gene length, protein length''' \|\| 888 bp, 296 aa~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\|'''Immediate neighbours''' \|\| ''[[ctpB]]'', ''[[ftsE]]''~~
−	\|-
−	\|style="background:#FAF8CC;" align="center"\|'''Sequences'''\|\|[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU35250 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU35250 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU35250 DNA_with_flanks]
−	\|-
−	~~\|colspan="2" \| '''Genetic context''' <br/> [[Image:ftsX_context.gif]]~~
−	~~<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>~~
−	\|-
−	\|colspan="2" \|'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ftsX_3623938_3624828_-1 Expression at a glance]'''   {{PubMed\|22383849}}<br/>[[Image:ftsX_expression.png\|500px\|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU35250]]
−	\|-
−	\|}
−
−	~~__TOC__~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/>~~
−
−	~~= [[Categories]] containing this gene/protein =~~
−	~~{{SubtiWiki category\|[[ABC transporters]]}},~~
−	~~{{SubtiWiki category\|[[cell wall synthesis]]}},~~
−	~~{{SubtiWiki category\|[[phosphorelay]]}},~~
−	~~{{SubtiWiki category\|[[membrane proteins]]}}~~
−
−	~~= This gene is a member of the following [[regulons]] =~~
−	~~{{SubtiWiki regulon\|[[Spo0A regulon]]}}~~
−
−	~~=The gene=~~
−
−	~~=== Basic information ===~~
−
−	* '''Locus tag:''' BSU35250
−
−	~~===Phenotypes of a mutant ===~~
−	* a ''[[ftsX]]'' mutation is synthetically lethal with a ''[[lytE]]'' mutation (due to a lack of autolysin activity) {{PubMed\|23869552,23855774}}
−	* shorter, fatter cells, this can be rescued by addition of Mg(2+) {{PubMed\|23869552,23855774}}
−	* reduced growth rate, especially at low Mg(2+) concentrations {{PubMed\|23869552}}
−
−	~~=== Database entries ===~~
−	* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU35250&redirect=T BSU35250]
−
−	* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/ftsEX.html]
−
−	* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG12591]
−
−	~~=== Additional information===~~
−
−
−
−	~~=The protein=~~
−
−	~~=== Basic information/ Evolution ===~~
−
−	* '''Catalyzed reaction/ biological activity:'''
−	** necessary for the autolysin activity of [[CwlO]] {{PubMed\|23855774}}
−
−	* '''Protein family:''' FtsX subfamily (according to Swiss-Prot)
−
−	* '''Paralogous protein(s):'''
−
−	~~=== Extended information on the protein ===~~
−
−	* '''Kinetic information:'''
−
−	* '''[[Domains]]:'''
−
−	* '''Modification:'''
−
−	* '''[[Cofactors]]:'''
−
−	* '''Effectors of protein activity:'''
−
−	* '''[[SubtInteract\|Interactions]]:'''
−	** [[FtsE]]-[[FtsX]] {{PubMed\|23869552,18573177}}
−	** [[FloT]]-[[FtsX]] {{PubMed\|23651456}}
−	** [[FtsX]]-[[CwlO]], at the membrane {{PubMed\|23869552}}
−
−	* '''[[Localization]]:'''
−	** cell membrane {{PubMed\|23869552}}
−
−	~~=== Database entries ===~~
−	* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU35250&redirect=T BSU35250]
−
−	* '''Structure:'''
−
−	* '''UniProt:''' [http://www.uniprot.org/uniprot/O34876 O34876]
−
−	* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU35250]
−
−	* '''E.C. number:'''
−
−	~~=== Additional information===~~
−
−	~~=Expression and regulation=~~
−	* '''Operon:''' ''[[ftsE]]-[[ftsX]]'' (according to [http://dbtbs.hgc.jp/COG/prom/ftsEX.html DBTBS])
−
−	* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ftsX_3623938_3624828_-1 ftsX] {{PubMed\|22383849}}
−
−	* '''[[Sigma factor]]:'''
−
−	* '''Regulation:'''
−	** repressed under conditions that trigger sporulation ([[Spo0A]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]
−
−	* '''Regulatory mechanism:'''
−	** [[Spo0A]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]
−
−	* '''Additional information:'''
−
−	~~=Biological materials =~~
−
−	* '''Mutant:'''
−
−	* '''Expression vector:'''
−
−	* '''lacZ fusion:'''
−
−	* '''GFP fusion:'''
−
−	* '''two-hybrid system:'''
−
−	* '''Antibody:'''
−
−	~~=Labs working on this gene/protein=~~
−
−	~~=Your additional remarks=~~
−
−	~~=References=~~
−
−	~~<pubmed>10092453,18573177,23651456,14651647,18763711, 23855774 23869552</pubmed>~~
−
−	~~[[Category:Protein-coding genes]]~~

@@ Line 60: / Line 60: @@
 === Database entries ===
 * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/ftsEX.html]
@@ Line 101: / Line 102: @@
 === Database entries ===
 * '''Structure:'''

@@ Line 1: / Line 1: @@
-* '''Description:''' [[ABC transporter]] (membrane protein) ([[FtsE]]-[[FtsX]]), required for [[CwlO]] activity and for proper activation of [[Spo0A]] and initiation of [[sporulation]] <br/><br/>
+* '''Description:''' [[ABC transporter]] (membrane protein) ([[FtsE]]-[[FtsX]]), required for [[CwlO]] activity (cell elongation) and for proper activation of [[Spo0A]] and initiation of [[sporulation]] <br/><br/>
 {| align="right" border="1" cellpadding="2"
@@ Line 55: / Line 55: @@
 ===Phenotypes of a mutant ===
-* a ''[[ftsX]]'' mutation is synthetically lethal with a ''[[lytE]]'' mutation (due to a lack of autolysin activity) {{PubMed|23855774}}
+* a ''[[ftsX]]'' mutation is synthetically lethal with a ''[[lytE]]'' mutation (due to a lack of autolysin activity) {{PubMed|23869552,23855774}}
-* shorter, fatter cells {{PubMed|23855774}}
+* shorter, fatter cells, this can be rescued by addition of Mg(2+) {{PubMed|23869552,23855774}}
 === Database entries ===
@@ Line 83: / Line 84: @@
 * '''Kinetic information:'''
-* '''Domains:'''
+* '''[[Domains]]:'''
 * '''Modification:'''
-* '''Cofactor(s):'''
+* '''[[Cofactors]]:'''
 * '''Effectors of protein activity:'''
 * '''[[SubtInteract|Interactions]]:'''
-** [[FtsE]]-[[FtsX]] {{PubMed|18573177}}
+** [[FtsE]]-[[FtsX]] {{PubMed|23869552,18573177}}
 ** [[FloT]]-[[FtsX]] {{PubMed|23651456}}
-* '''[[Localization]]:''' cell membrane (according to Swiss-Prot),  membrane associated [http://www.ncbi.nlm.nih.gov/pubmed/18763711 PubMed]
+* '''[[Localization]]:'''
 === Database entries ===
@@ Line 144: / Line 147: @@
 =References=
-<pubmed>10092453,18573177,23651456,14651647,18763711, 23855774</pubmed>
+<pubmed>10092453,18573177,23651456,14651647,18763711, 23855774 23869552</pubmed>
 [[Category:Protein-coding genes]]

@@ Line 16: / Line 16: @@
 |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU35250 ftsX]
 |-
-|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/FtsX FtsX]
+|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=FtsX FtsX]
 |-
 |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 32 kDa, 10.016

@@ Line 55: / Line 55: @@
 ===Phenotypes of a mutant ===
-* a ''[[ftsX]]'' mutation is synthetically lethal with a ''[[lytE]]'' mutation (due to a lack of autolysin activity) {{PubMed|xxx}}
+* a ''[[ftsX]]'' mutation is synthetically lethal with a ''[[lytE]]'' mutation (due to a lack of autolysin activity) {{PubMed|23855774}}
-* shorter, fatter cells {{PubMed|xxx}}
+* shorter, fatter cells {{PubMed|23855774}}
 === Database entries ===
@@ Line 73: / Line 73: @@
 * '''Catalyzed reaction/ biological activity:'''
-** necessary for the autolysin activity of [[CwlO]] {{PubMed|xxx}}
+** necessary for the autolysin activity of [[CwlO]] {{PubMed|23855774}}
 * '''Protein family:''' FtsX subfamily (according to Swiss-Prot)
@@ Line 144: / Line 144: @@
 =References=
-<pubmed>10092453,18573177,23651456,14651647,18763711, </pubmed>
+<pubmed>10092453,18573177,23651456,14651647,18763711, 23855774</pubmed>
 [[Category:Protein-coding genes]]

@@ Line 1: / Line 1: @@
-* '''Description:''' [[ABC transporter]] (membrane protein) ([[FtsE]]-[[FtsX]]), required for proper activation of [[Spo0A]] and initiation of sporulation <br/><br/>
+* '''Description:''' [[ABC transporter]] (membrane protein) ([[FtsE]]-[[FtsX]]), required for [[CwlO]] activity and for proper activation of [[Spo0A]] and initiation of [[sporulation]] <br/><br/>
 {| align="right" border="1" cellpadding="2"
@@ Line 12: / Line 12: @@
 |style="background:#ABCDEF;" align="center"| '''Product''' || [[ABC transporter]] (membrane protein)
 |-
-|style="background:#ABCDEF;" align="center"|'''Function''' || initiation of sporulation
+|style="background:#ABCDEF;" align="center"|'''Function''' || control of [[cell wall synthesis]]
 |-
 |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU35250 ftsX]
@@ Line 41: / Line 41: @@
 = [[Categories]] containing this gene/protein =
 {{SubtiWiki category|[[ABC transporters]]}},
 {{SubtiWiki category|[[phosphorelay]]}},
 {{SubtiWiki category|[[membrane proteins]]}}
@@ Line 54: / Line 55: @@
 ===Phenotypes of a mutant ===
 === Database entries ===
@@ Line 62: / Line 65: @@
 === Additional information===
@@ Line 71: / Line 73: @@
 * '''Catalyzed reaction/ biological activity:'''
 * '''Protein family:''' FtsX subfamily (according to Swiss-Prot)

@@ Line 29: / Line 29: @@
   <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
 |-
-|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ftsX_3623938_3624828_-1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:ftsX_expression.png|500px]]
+|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ftsX_3623938_3624828_-1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:ftsX_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU35250]]
 |-
 |}

@@ Line 24: / Line 24: @@
 |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ctpB]]'', ''[[ftsE]]''
 |-
-|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU35250 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU35250 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU35250 Advanced_DNA]
+|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU35250 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU35250 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU35250 DNA_with_flanks]
 |-
 |colspan="2" | '''Genetic context''' <br/> [[Image:ftsX_context.gif]]

@@ Line 37: / Line 37: @@
 <br/><br/><br/><br/>
 <br/><br/><br/><br/>
 <br/><br/>
@@ Line 94: / Line 90: @@
 * '''[[SubtInteract|Interactions]]:'''
 ** [[FtsE]]-[[FtsX]] {{PubMed|18573177}}
 * '''[[Localization]]:''' cell membrane (according to Swiss-Prot),  membrane associated [http://www.ncbi.nlm.nih.gov/pubmed/18763711 PubMed]
@@ Line 114: / Line 111: @@
 * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ftsX_3623938_3624828_-1 ftsX] {{PubMed|22383849}}
-* '''Sigma factor:'''
+* '''[[Sigma factor]]:'''
 * '''Regulation:'''
@@ Line 144: / Line 141: @@
 =References=
-<pubmed>10092453,18573177,,14651647,18763711, </pubmed>
+<pubmed>10092453,18573177,23651456,14651647,18763711, </pubmed>
 [[Category:Protein-coding genes]]