CtpB - Revision history

134.76.70.252 at 10:07, 17 April 2014

2014-04-17T10:07:45Z

134.76.38.147 at 14:55, 2 April 2014

2014-04-02T14:55:07Z

Jstuelk: /* Database entries */

2013-12-03T10:17:31Z

‎Database entries

Jstuelk: /* Extended information on the protein */

2013-12-03T10:07:52Z

‎Extended information on the protein

Jstuelk: /* Basic information/ Evolution */

2013-12-03T10:06:44Z

‎Basic information/ Evolution

Jstuelk at 10:05, 3 December 2013

2013-12-03T10:05:41Z

Jstuelk at 10:03, 3 December 2013

2013-12-03T10:03:01Z

Jstuelk at 09:43, 3 December 2013

2013-12-03T09:43:48Z

134.76.70.252 at 14:41, 16 May 2013

2013-05-16T14:41:41Z

134.76.70.252 at 11:23, 14 May 2013

2013-05-14T11:23:45Z

← Older revision		Revision as of 10:07, 17 April 2014
Line 1:		Line 1:
−	* '''Description:~~''' carboxy-terminal processing serine protease, cleaves [[SpoIVFA]], this results in processing of pro-[[SigK]] <br/><br/>~~	+	{{#bank: CtpB}}

−	~~{\| align="right" border="1" cellpadding="2"~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\|'''Gene name'''~~
−	~~\|''ctpB''~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Synonyms''' \|\| ''yvjB ''~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Essential''' \|\| no~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Product''' \|\| carboxy-terminal processing serine protease, <br/>cleaves SpoIVFA~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\|'''Function''' \|\| control of [[SigK]] activation~~
−	\|-
−	\|colspan="2" style="background:#FAF8CC;" align="center"\| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU35240 ctpB]
−	\|-
−	\|colspan="2" style="background:#FAF8CC;" align="center"\| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=CtpB CtpB]
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''MW, pI''' \|\| 52 kDa, 8.641~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Gene length, protein length''' \|\| 1440 bp, 480 aa~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\|'''Immediate neighbours''' \|\| ''[[swrAA/2]]'', ''[[ftsX]]''~~
−	\|-
−	\|style="background:#FAF8CC;" align="center"\|'''Sequences'''\|\|[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU35240 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU35240 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU35240 DNA_with_flanks]
−	\|-
−	~~\|colspan="2" \| '''Genetic context''' <br/> [[Image:yvjB_context.gif]]~~
−	~~<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>~~
−	\|-
−	\|colspan="2" \|'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ctpB_3622356_3623798_-1 Expression at a glance]'''   {{PubMed\|22383849}}<br/>[[Image:ctpB_expression.png\|500px\|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU35240]]
−	\|-
−	\|}
−
−	~~__TOC__~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/>~~
−
−	~~= [[Categories]] containing this gene/protein =~~
−	~~{{SubtiWiki category\|[[proteolysis]]}},~~
−	~~{{SubtiWiki category\|[[sigma factors and their control]]}},~~
−	~~{{SubtiWiki category\|[[sporulation proteins]]}}~~
−
−	~~= This gene is a member of the following [[regulons]] =~~
−	~~{{SubtiWiki regulon\|[[SigE regulon]]}},~~
−	~~{{SubtiWiki regulon\|[[SigG regulon]]}}~~
−
−	~~=The gene=~~
−
−	~~=== Basic information ===~~
−
−	* '''Locus tag:''' BSU35240
−
−	~~===Phenotypes of a mutant ===~~
−
−	~~=== Database entries ===~~
−	* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU35240&redirect=T BSU35240]
−
−	* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/ctpB.html]
−
−	* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG14110]
−
−	~~=== Additional information===~~
−
−
−
−
−	~~=The protein=~~
−
−	~~=== Basic information/ Evolution ===~~
−
−	* '''Catalyzed reaction/ biological activity:'''
−
−	* '''Protein family:''' PDZ protease {{PubMed\|24243021}}
−
−	* '''Paralogous protein(s):''' [[CtpA]]
−
−	~~=== Extended information on the protein ===~~
−
−	* '''Kinetic information:'''
−
−	* '''Domains:'''
−
−	* '''Modification:'''
−
−	* '''[[Cofactors]]:'''
−
−	* '''Effectors of protein activity:'''
−	** substrate binding of CtpB induces opening of the PDZ gate and protease activation {{PubMed\|24243021}}
−	** [[CtpB]] acts in concert with a second signaling protease, [[SpoIVB]] {{PubMed\|24243021}}
−
−	* '''[[SubtInteract\|Interactions]]:'''
−	** forms a dimeric ring {{PubMed\|24243021}}
−	** [[CtpB]]-[[SpoIVFA]] {{PubMed\|24243021}}
−
−	* '''[[Localization]]:'''
−	** intracellular space between the mother cell and the forespore {{PubMed\|24243021}}
−
−	~~=== Database entries ===~~
−	* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU35240&redirect=T BSU35240]
−
−	* '''Structure:'''
−	** [http://www.pdb.org/pdb/search/structidSearch.do?structureId=4c2c 4C2C] {{PubMed\|24243021}}
−	** forms a ring-like scaffold with two narrow tunnels for substrate binding {{PubMed\|24243021}}
−
−	* '''UniProt:''' [http://www.uniprot.org/uniprot/O35002 O35002]
−
−	* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU35240]
−
−	* '''E.C. number:'''
−
−	~~=== Additional information===~~
−
−	~~=Expression and regulation=~~
−
−	* '''Operon:''' ''ctpB'' (according to [http://dbtbs.hgc.jp/COG/prom/ctpB.html DBTBS])
−
−	* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ctpB_3622356_3623798_-1 ctpB] {{PubMed\|22383849}}
−
−	* '''Sigma factor:''' [[SigE]] {{PubMed\|15699190}}, [[SigG]] {{PubMed\|15699190,16497325}}
−
−	* '''Regulation:''' expressed during sporulation ([[SigE]], [[SigG]]) {{PubMed\|15699190,16497325}}
−
−	* '''Regulatory mechanism:'''
−
−	* '''Additional information:'''
−
−	~~=Biological materials =~~
−
−	* '''Mutant:'''
−	** 1S129 ( ''ctpB''::''tet''), {{PubMed\|14526016}}, available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S129&Search=1S129 BGSC]
−
−	* '''Expression vector:'''
−
−	* '''lacZ fusion:'''
−
−	* '''GFP fusion:'''
−
−	* '''two-hybrid system:'''
−
−	* '''Antibody:'''
−
−	~~=Labs working on this gene/protein=~~
−
−	~~=Your additional remarks=~~
−
−	~~=References=~~
−
−	~~<pubmed>14526016, 17557826, 16818230 15699190,16497325 24243021 </pubmed>~~
−
−	~~[[Category:Protein-coding genes]]~~

@@ Line 57: / Line 57: @@
 === Database entries ===
 * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/ctpB.html]
@@ Line 99: / Line 100: @@
 === Database entries ===
 * '''Structure:'''

← Older revision		Revision as of 10:17, 3 December 2013
Line 101:		Line 101:

	* '''Structure:'''		* '''Structure:'''
		+	** [http://www.pdb.org/pdb/search/structidSearch.do?structureId=4c2c 4C2C] {{PubMed\|24243021}}
	** forms a ring-like scaffold with two narrow tunnels for substrate binding {{PubMed\|24243021}}		** forms a ring-like scaffold with two narrow tunnels for substrate binding {{PubMed\|24243021}}

← Older revision		Revision as of 10:07, 3 December 2013
Line 92:		Line 92:

	* '''[[SubtInteract\|Interactions]]:'''		* '''[[SubtInteract\|Interactions]]:'''
		+	** forms a dimeric ring {{PubMed\|24243021}}
	** [[CtpB]]-[[SpoIVFA]] {{PubMed\|24243021}}		** [[CtpB]]-[[SpoIVFA]] {{PubMed\|24243021}}

@@ Line 73: / Line 73: @@
 * '''Catalyzed reaction/ biological activity:'''
-* '''Protein family:'''
+* '''Protein family:''' PDZ protease {{PubMed|24243021}}
 * '''Paralogous protein(s):''' [[CtpA]]

@@ Line 15: / Line 15: @@
 |-
 |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU35240 ctpB]
 |-
 |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 52 kDa, 8.641

@@ Line 87: / Line 87: @@
 * '''Effectors of protein activity:'''
 ** substrate binding of CtpB induces opening of the PDZ gate and protease activation {{PubMed|24243021}}
 * '''[[SubtInteract|Interactions]]:'''
 * '''[[Localization]]:'''

@@ Line 35: / Line 35: @@
 <br/><br/><br/><br/>
 <br/><br/><br/><br/>
-<br/><br/><br/><br/>
+<br/><br/>
 = [[Categories]] containing this gene/protein =
@@ Line 87: / Line 83: @@
 * '''Modification:'''
-* '''Cofactor(s):'''
+* '''[[Cofactors]]:'''
 * '''Effectors of protein activity:'''
+** substrate binding of CtpB induces opening of the PDZ gate and protease activation {{PubMed|24243021}}
 * '''[[SubtInteract|Interactions]]:'''
 * '''[[Localization]]:'''
 === Database entries ===
 * '''Structure:'''
 * '''UniProt:''' [http://www.uniprot.org/uniprot/O35002 O35002]
@@ Line 142: / Line 140: @@
 =References=
-<pubmed>14526016, 17557826, 16818230 15699190,16497325</pubmed>
+<pubmed>14526016, 17557826, 16818230 15699190,16497325 24243021 </pubmed>
 [[Category:Protein-coding genes]]

@@ Line 27: / Line 27: @@
   <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
 |-
-|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ctpB_3622356_3623798_-1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:ctpB_expression.png|500px]]
+|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ctpB_3622356_3623798_-1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:ctpB_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU35240]]
 |-
 |}

@@ Line 22: / Line 22: @@
 |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[swrAA/2]]'', ''[[ftsX]]''
 |-
-|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU35240 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU35240 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU35240 Advanced_DNA]
+|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU35240 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU35240 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU35240 DNA_with_flanks]
 |-
 |colspan="2" | '''Genetic context''' <br/> [[Image:yvjB_context.gif]]