ComS - Revision history

134.76.38.147 at 12:58, 2 April 2014

2014-04-02T12:58:07Z

Jstuelk at 11:39, 16 March 2014

2014-03-16T11:39:58Z

Jstuelk at 11:33, 16 March 2014

2014-03-16T11:33:51Z

134.76.70.252 at 15:11, 11 November 2013

2013-11-11T15:11:05Z

Jstuelk at 19:23, 18 June 2013

2013-06-18T19:23:58Z

134.76.70.252 at 12:31, 16 May 2013

2013-05-16T12:31:57Z

134.76.70.252 at 09:27, 14 May 2013

2013-05-14T09:27:34Z

134.76.70.252 at 12:07, 13 May 2013

2013-05-13T12:07:32Z

Jstuelk: /* Original Publications */

2013-03-27T10:07:11Z

‎Original Publications

Jstuelk: /* Original Publications */

2013-03-27T10:06:55Z

‎Original Publications

← Older revision		Revision as of 12:58, 2 April 2014
Line 1:		Line 1:
−	* '''Description:~~''' antiadaptor protein, assembly link between regulatory components of the competence signal transduction pathway <br/><br/>~~	+	{{#bank: ComS}}

−	~~{\| align="right" border="1" cellpadding="2"~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\|'''Gene name'''~~
−	~~\|''comS''~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Synonyms''' \|\| '' ''~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Essential''' \|\| no~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Product''' \|\| antiadaptor protein (anti-[[MecA]])~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\|'''Function''' \|\| control of [[ComK]] degradation~~
−	\|-
−	\|colspan="2" style="background:#FAF8CC;" align="center"\| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU03500 comS]
−	\|-
−	\|colspan="2" style="background:#FAF8CC;" align="center"\| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=ComS ComS]
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''MW, pI''' \|\| 5 kDa, 9.145~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Gene length, protein length''' \|\| 138 bp, 46 aa~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\|'''Immediate neighbours''' \|\| ''[[srfAB]]'', ''[[srfAC]]''~~
−	\|-
−	\|style="background:#FAF8CC;" align="center"\|'''Sequences'''\|\|[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU03500 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU03500 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU03500 DNA_with_flanks]
−	\|-
−	~~\|colspan="2" \| '''Genetic context''' <br/> [[Image:comS_context.gif]]~~
−	~~<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>~~
−	\|-
−	\|colspan="2" \|'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=comS_390880_391020_1 Expression at a glance]'''   {{PubMed\|22383849}}<br/>[[Image:comS_expression.png\|500px\|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU03500]]
−	\|-
−	\|}
−
−	~~__TOC__~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/>~~
−
−	~~= [[Categories]] containing this gene/protein =~~
−	~~{{SubtiWiki category\|[[genetic competence]]}},~~
−	~~{{SubtiWiki category\|[[short peptides]]}}~~
−
−	~~= This gene is a member of the following [[regulons]] =~~
−	~~{{SubtiWiki regulon\|[[Abh regulon]]}},~~
−	~~{{SubtiWiki regulon\|[[CodY regulon]]}},~~
−	~~{{SubtiWiki regulon\|[[ComA regulon]]}},~~
−	~~{{SubtiWiki regulon\|[[PerR regulon]]}},~~
−	~~{{SubtiWiki regulon\|[[Spx regulon]]}}~~
−
−	~~=The gene=~~
−
−	~~=== Basic information ===~~
−
−	* '''Locus tag:''' BSU03500
−
−	~~===Phenotypes of a mutant ===~~
−	* loss of [[genetic competence]] {{PubMed\|7752896}}
−	* overexpression of [[ComS]] results in expression of competence genes in 80% to 90% of the cells {{PubMed\|8878039}}
−
−	~~=== Database entries ===~~
−
−	* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/srfAA-srfAB-comS-srfAC-srfAD.html]
−
−	* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11045]
−
−	~~=== Additional information===~~
−
−	~~=The protein=~~
−
−	~~=== Basic information/ Evolution ===~~
−
−	* '''Catalyzed reaction/ biological activity:'''
−
−	* '''Protein family:'''
−
−	* '''Paralogous protein(s):'''
−
−	~~=== Extended information on the protein ===~~
−
−	* '''Kinetic information:'''
−
−	* '''[[Domains]]:'''
−
−	* '''Modification:'''
−
−	* '''[[Cofactors]]:'''
−
−	* '''Effectors of protein activity:'''
−
−	* '''[[SubtInteract\|Interactions]]:'''
−	**[[MecA]]-[[ComS]] [http://www.ncbi.nlm.nih.gov/sites/entrez/10447896 PubMed]
−
−	* '''[[Localization]]:'''
−
−	~~=== Database entries ===~~
−
−	* '''Structure:'''
−
−	* '''UniProt:''' [http://www.uniprot.org/uniprot/P80355 P80355]
−
−	* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU03500]
−
−	* '''E.C. number:'''
−
−	~~=== Additional information===~~
−
−	~~=Expression and regulation=~~
−
−	* '''Operon:''' ''[[srfAA]]-[[srfAB]]-[[comS]]-[[srfAC]]-[[srfAD]]'' {{PubMed\|1715856}}
−
−	* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=comS_390880_391020_1 comS] {{PubMed\|22383849}}
−
−	* '''[[Sigma factor]]:''' [[SigA]] {{PubMed\|1715856}}
−
−	* '''Regulation:'''
−	** repressed during growth in the presence of branched chain amino acids ([[CodY]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8830686 PubMed]
−	** repressed during hydrogen peroxide stress ([[PerR]]) {{PubMed\|16166527}}
−	** expressed at high cell density ([[ComA]]) {{PubMed\|16091051}}
−
−	* '''Regulatory mechanism:'''
−	** [[CodY]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/8830686 PubMed]
−	** [[ComA]]: transcription activation {{PubMed\|1715856,16091051}}
−	** [[PerR]]: transcription activation {{PubMed\|16166527}}
−	** [[Spx]]: transcription repression {{PubMed\|12642660}}
−	** [[Abh]]: transcription repression{{PubMed\|20817675}}
−
−	* '''Additional information:'''
−
−	~~=Biological materials =~~
−
−	* '''Mutant:'''
−
−	* '''Expression vector:'''
−
−	* '''lacZ fusion:'''
−
−	* '''GFP fusion:'''
−
−	* '''two-hybrid system:'''
−
−	* '''Antibody:'''
−
−	~~=Labs working on this gene/protein=~~
−
−	~~=Your additional remarks=~~
−
−	~~=References=~~
−
−	~~==Reviews==~~
−	~~<pubmed> 19609260</pubmed>~~
−
−	~~==Original Publications==~~
−	~~<pubmed>17560370,10447896, 12642660,9000055, 10361283, 10447896, 11703662 1715856 16091051 20817675 8878039 7752896</pubmed>~~
−
−	~~[[Category:Protein-coding genes]]~~

@@ Line 57: / Line 57: @@
 ===Phenotypes of a mutant ===
 * overexpression of [[ComS]] results in expression of competence genes in 80% to 90% of the cells {{PubMed|8878039}}
@@ Line 152: / Line 153: @@
 ==Original Publications==
-<pubmed>17560370,10447896, 12642660,9000055, 10361283, 10447896, 11703662 1715856 16091051 20817675 8878039</pubmed>
+<pubmed>17560370,10447896, 12642660,9000055, 10361283, 10447896, 11703662 1715856 16091051 20817675 8878039 7752896</pubmed>
 [[Category:Protein-coding genes]]

@@ Line 57: / Line 57: @@
 ===Phenotypes of a mutant ===
 === Database entries ===
@@ Line 65: / Line 66: @@
 === Additional information===
 =The protein=
@@ Line 83: / Line 81: @@
 * '''Kinetic information:'''
-* '''Domains:'''
+* '''[[Domains]]:'''
 * '''Modification:'''
-* '''Cofactor(s):'''
+* '''[[Cofactors]]:'''
 * '''Effectors of protein activity:'''
@@ Line 154: / Line 152: @@
 ==Original Publications==
-<pubmed>17560370,10447896, 12642660,9000055, 10361283, 10447896, 11703662 1715856 16091051 20817675</pubmed>
+<pubmed>17560370,10447896, 12642660,9000055, 10361283, 10447896, 11703662 1715856 16091051 20817675 8878039</pubmed>
 [[Category:Protein-coding genes]]

@@ Line 16: / Line 16: @@
 |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU03500 comS]
 |-
-|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/ComS ComS]
+|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=ComS ComS]
 |-
 |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 5 kDa, 9.145

@@ Line 37: / Line 37: @@
 <br/><br/><br/><br/>
 <br/><br/><br/><br/>
 <br/><br/>
@@ Line 118: / Line 114: @@
 * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=comS_390880_391020_1 comS] {{PubMed|22383849}}
-* '''Sigma factor:''' [[SigA]] {{PubMed|1715856}}
+* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|1715856}}
 * '''Regulation:'''

@@ Line 29: / Line 29: @@
   <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
 |-
-|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=comS_390880_391020_1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:comS_expression.png|500px]]
+|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=comS_390880_391020_1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:comS_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU03500]]
 |-
 |}

@@ Line 24: / Line 24: @@
 |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[srfAB]]'', ''[[srfAC]]''
 |-
-|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU03500 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU03500 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU03500 Advanced_DNA]
+|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU03500 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU03500 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU03500 DNA_with_flanks]
 |-
 |colspan="2" | '''Genetic context''' <br/> [[Image:comS_context.gif]]

@@ Line 160: / Line 160: @@
 '''Additional publications:''' {{PubMed|20817675}}
-<pubmed>17560370,10447896, 12642660,9000055, 10361283, 10447896, 11703662 1715856 16091051</pubmed>
+<pubmed>17560370,10447896, 12642660,9000055, 10361283, 10447896, 11703662 1715856 16091051 20817675</pubmed>
 [[Category:Protein-coding genes]]