atpD

atpD
168

ATP synthase, part of the F1 complex (subunit beta)

locus
BSU_36810
Molecular weight
51.26 kDa
pI
4.61
Protein length
Gene length
function
ATP synthesis
product
ATP synthase (subunit beta))
essential
no
ec
3.6.3.14
synonyms
atpD

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0055 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,781,491 3,782,912
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The protein
Catalyzed reaction/ biological activity
ATP + 4 H+ + H2O --> ADP + 5 H+ + phosphate (according to UniProt), ATP synthesis [http://www.youtube.com/watch?v=uOoHKCMAUMc see a video]
Protein family
ATPase alpha/beta chains family (with [protein|E3FADE979CE6AB6315F67812608FCE00CF4E2453|atpA] and [protein|401459F105BC8A8342341D953AE259D6C3868AB6|fliI], according to UniProt)
Structure
[PDB|1SKY] ([protein|E3FADE979CE6AB6315F67812608FCE00CF4E2453|atpA]-[protein|2A566C2CF8F7B86E05EEF4B7A268E8C102070025|atpD] complex from ''Bacillus sp.'', 88% identity) [Pubmed|9261073]
[PDB|see here an overview on ATPase structure]
[AF|P37809]
Modification
phosphorylated on ser/ thr/ tyr [Pubmed|16493705]
Effectors of protein activity
ATPase activity is inhibited upon binding of Mg-ADP to [protein|2A566C2CF8F7B86E05EEF4B7A268E8C102070025|atpD] [pubmed|30580998]
[wiki|Localization]
membrane [Pubmed|18763711]
peripheral via theF0 complex
Additional information
belongs to the 100 most abundant proteins [PubMed|15378759]
Expression and Regulation
Operons
genes
[gene|8027AD5C3A92FB9B70E42C119FDEC697A64618C4|atpI]-[gene|CC1894D90AC17487A286B2909964916825055F93|atpB]-[gene|6CF7F6303425D8A51E1E01BF18823139E4259A8F|atpE]-[gene|87311FEA265AD3F5526C78D631E7E51BBF01F0D6|atpF]-[gene|E956A30D97B2941108880F3AD48620C4DB6E0EBD|atpH]-[gene|E3FADE979CE6AB6315F67812608FCE00CF4E2453|atpA]-[gene|492EEC8068043DA770F5DC1D54799C4366AE9A01|atpG]-[gene|2A566C2CF8F7B86E05EEF4B7A268E8C102070025|atpD]-[gene|A9DA64F8C7A60E8E2B1EDC99BEA1BD7DD0135AA6|atpC]
description
[Pubmed|9353933]
regulation
[protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|rel] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
the mRNA is processed between [gene|8027AD5C3A92FB9B70E42C119FDEC697A64618C4|atpI] and [gene|CC1894D90AC17487A286B2909964916825055F93|atpB] by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y], this requires the [protein|EE52DFA35B935E551871D079A9BE877DB2001A3B|ricA]-[protein|6C9A092F38739A3759793EF8B496569CD02C2E3F|ricF]-[protein|EBD15C174A03B7FCDFFE4C5DB5D86E93F1B9CAC4|ricT] complex [Pubmed|29794222]
regulatory mechanism
stringent response: negative regulation, in [regulon|other_regulator:stringent response|stringent response]
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[gene|8027AD5C3A92FB9B70E42C119FDEC697A64618C4|atpI]→[gene|A9DA64F8C7A60E8E2B1EDC99BEA1BD7DD0135AA6|atpC]

2024-05-13 06:23:48

Jstuelk

90

c30b9914547f38015d481b305686327f4f8f18d8

1C7DF7F5F812B06EFE55424A9900C106B30D346A

Biological materials
Mutant
BKE36810 ([gene|2A566C2CF8F7B86E05EEF4B7A268E8C102070025|atpD]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE36810 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCGCTATCCCTCCTGACA, downstream forward: _UP4_TAATCTGGTCCTAGGAGGGT
BKK36810 ([gene|2A566C2CF8F7B86E05EEF4B7A268E8C102070025|atpD]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK36810 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCGCTATCCCTCCTGACA, downstream forward: _UP4_TAATCTGGTCCTAGGAGGGT
References
Reviews
23356252,23341301,23267178,22822068,21524994,19489730,17208001,16730323
Original Publications
36815589,7961438,15378759,16493705,18763711,9261073,28516784,30580998

2A566C2CF8F7B86E05EEF4B7A268E8C102070025

Page visits: 3840

Time of last update: 2024-05-23 08:45:27

Author of last update: Jstuelk