SubtiBank SubtiBank
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Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)2025-05-14 22:05:06

description

ribosomal protein

ribosomal protein L22, important for folding and stabilization of the conformation of 23S rRNA

locus

BSU01210

BSU_01210

essential

no

yes

ec

outlinks

bsu

BSU01210

BSU_01210

[SW|Categories] containing this gene/protein

[SW|translation], [SW|universally conserved proteins]

Gene

Coordinates on the chromosome (coding sequence)

138,497 -> 138,838

The protein

Protein family

[SW|ribosomal protein] L22P family (according to Swiss-Prot)

universal [SW|ribosomal protein] uL22 family (single member, according to UniProt)

The protein

[SW|Interactions]

[[protein|DefA]]-[[protein|RplV]] [Pubmed|18288106]

[[protein|RplV]]-[[protein|MifM]] [Pubmed|25903689]

Expression and Regulation

Operon

''[[protein|rpsJ]]-[[protein|rplC]]-[[protein|rplD]]-[[protein|rplW]]-[[protein|rplB]]-[[protein|rpsS]]-[[protein|rplV]]-[[protein|rpsC]]-[[protein|rplP]]-[[protein|rpmC]]-[[protein|rpsQ]]-[[protein|rplN]]-[[protein|rplX]]-[[protein|rplE]]-[[protein|rpsN]]-[[protein|rpsH]]-[[protein|rplF]]-[[protein|rplR]]-[[protein|rpsE]]-[[protein|rpmD]]-[[protein|rplO]]'' [Pubmed|9371452]

Expression and Regulation

[SW|Sigma factor]

[[protein|SigA]] two promoters, about 140bp and 200bp upstream of the start codon [Pubmed|9371452]

Expression and Regulation

Regulation

[[protein|RelA]] dependent downregulation (Class I) during stringent response [Pubmed|11948165]

References

19653700, 9371452, 11948165, 8635744, 23002217, 18288106, 25903689

19653700, 9371452, 11948165, 8635744, 23002217, 18288106, 25903689, 25903689, 28189581, 30853217

proteinLength

113

geneLength

342

Gene

Coordinates

138,497 → 138,838

Gene

Phenotypes of a mutant

essential [Pubmed|28189581]

loop duplication results in increased growth rate [pubmed|30853217]

loop duplication results in reduced hyperpolarization of cells [pubmed|30853217]

loop duplication results in increased expression of [[gene|mgtE]] [pubmed|30853217]

The protein

Paralogous protein(s)

[[this]]

The protein

Structure

[PDB|3J9W] (the [SW|ribosome]) [Pubmed|25903689]

The protein

[SW|Localization]

[SW|ribosome]

Expression and Regulation

Operons

[[this]]

Expression and Regulation

Other regulations

[[this]]

Biological materials

Mutant

BKE01210 (Δ[[gene|rplV]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE01210 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTAAAAGCCTCCTCTCT, downstream forward: _UP4_TCAGAAAAGAAGGAGGGATA