Tue Oct 13 2015 12:43:06 GMT+0200 (CEST)2025-05-14 21:22:57
description
ABC transporter for the siderophores Fe-enterobactin and Fe-bacillibactin (integral membrane protein)
[SW|ABC transporter ]for the siderophores Fe-enterobactin and Fe-bacillibactin (integral membrane protein)
locus
BSU01610
BSU_01610
function
acquisition of iron
[SW|acquisition of iron]
product
ABC transporter for the siderophores Fe-enterobactin and
Fe-bacillibactin (integral membrane protein)
[SW|ABC transporter ]for the siderophores Fe-enterobactin and Fe-bacillibactin (integral membrane protein)
ec
outlinks
bsu
BSU01610
BSU_01610
[SW|Categories] containing this gene/protein
[SW|ABC transporters], [SW|acquisition of iron], [SW|iron metabolism], [SW|membrane proteins]
The protein
Protein family
FecCD subfamily (according to Swiss-Prot)
[SW|Binding-protein-dependent transport system permease family] (according to UniProt)
[SW|FecCD subfamily] (according to UniProt)
The protein
[SW|Interactions]
[[protein|YusV]]-([[protein|FeuB]]-[[protein|FeuC]])-[[protein|FeuA]] [Pubmed|10092453]
Expression and Regulation
Operon
''[[protein|feuA]]-[[protein|feuB]]-[[protein|feuC]]-[[protein|ybbA]]'' [Pubmed|12354229]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigA]] [Pubmed|17725565]
Expression and Regulation
Regulation
repressed in the presence of iron ([[protein|Fur]], [[protein|CitB]]) [Pubmed|12354229]
induced in the presence of iron chelators bacillibactin or enterobactin ([[protein|Btr]]) [Pubmed|17725565]
Expression and Regulation
Regulatory mechanism
[[protein|Fur]]: transcription repression [Pubmed|12354229]
[[protein|CitB]]: binding to the iron responsive element in the absence of iron
[[protein|Btr]]: transcription activation in the presence of the co-activators bacillibactin or enterobactin [Pubmed|17725565]
References
proteinLength
336
geneLength
1011
Gene
Coordinates
180,344 → 181,354
The protein
Paralogous protein(s)
[[this]]
The protein
Structure
[PDB|4G1U] (heme transporter from Yersinia pestis, 31% identity) [pubmed|23142986]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
BKE01610 (Δ[[gene|feuC]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE01610 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAAGCGATGAACAATGCAT, downstream forward: _UP4_AAGCAAAAAAAGGGGGAGAA
BKK01610 (Δ[[gene|feuC]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK01610 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAAGCGATGAACAATGCAT, downstream forward: _UP4_AAGCAAAAAAAGGGGGAGAA