Sun Oct 25 2015 18:14:12 GMT+0100 (CET)2025-05-09 14:24:03
locus
BSU23260
BSU_23260
outlinks
bsu
BSU23260
BSU_23260
[SW|Categories] containing this gene/protein
[SW|biosynthesis of cofactors]
The protein
Catalyzed reaction/ biological activity
D-ribulose 5-phosphate = formate L-3,4-dihydroxybutan-2-one 4-phosphate (according to Swiss-Prot)
D-ribulose 5-phosphate --> (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H+ (according to UniProt)
GTP + 3 H2O --> 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 2 H+ (according to UniProt)
Expression and Regulation
Operon
''[[protein|ribD]]-[[protein|ribE]]-[[protein|ribA]]-[[protein|ribH]]-[[protein|ribT]]'' [Pubmed|8159171]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigA]] [Pubmed|8159171]
Expression and Regulation
Regulation
expressed in the absence of FMN ([[protein|FMN-box]]) [Pubmed|15808508]
Expression and Regulation
Regulatory mechanism
[[protein|FMN-box]]: [SW|riboswitch], mediates termination/ antitermination control of the operon, in the absence of FMN: antitermination, in the presence of FMN: termination [Pubmed|15808508]
References
proteinLength
398
geneLength
1197
Gene
Coordinates
2,428,389 → 2,429,585
The protein
Protein family
N-terminal part: DHBP synthase family (single member, according to UniProt)
C-terminal part: GTP cyclohydrolase II family (single member, according to UniProt)
The protein
Paralogous protein(s)
[[this]]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
BKE23260 (Δ[[gene|ribA]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE23260 BGSC], [Pubmed|28189581], upstream reverse: _UP1_ATGAAACATGCAAATCTTCC, downstream forward: _UP4_TAATCACAAATATCACAAAA
BKK23260 (Δ[[gene|ribA]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK23260 BGSC], [Pubmed|28189581], upstream reverse: _UP1_ATGAAACATGCAAATCTTCC, downstream forward: _UP4_TAATCACAAATATCACAAAA