2019-05-21 17:30:242025-04-27 13:29:55
description
chromosome positioning near the pole and transport through the polar septum / antagonist of SMC complex to the origin of replication
CTP hydrolase, chromosome positioning near the pole and transport through the polar septum / antagonist of SMC complex to the origin of replication, coordination of early steps in DNA replication with establishment of a medial division site
locus
BSU40960
BSU_40960
outlinks
bsu
BSU40960
BSU_40960
The protein
Catalyzed reaction/ biological activity
forms DNA bridging interactions around parS to condense DNA and earmark the bacterial chromosome for segregation [pubmed|29244022]
inhibits [[protein|ParA]] dimerization and concomitant DNA-binding activity by stimulating [[protein|ParA]] ATPase activity [Pubmed|21235642]
recruits the condensin complex to the DNA origin region [Pubmed|24440393]
the dimer binds specifcally to the centromere-like ''parS'' sequence [Pubmed|25572315]
forms DNA bridging interactions around parS to condense DNA and earmark the bacterial chromosome for segregation [pubmed|29244022]
inhibits [[protein|ParA]] dimerization and concomitant DNA-binding activity by stimulating [[protein|ParA]] ATPase activity [Pubmed|21235642]
recruits the condensin complex to the DNA origin region [Pubmed|24440393]
the dimer binds specifcally to the centromere-like ''parS'' sequence [Pubmed|25572315]
prevents Z ring assembly over the bacterial nucleoid and helps fine tune the assembly of the Z ring at midcell during the cell cycle [pubmed|31152469]
The protein
Protein family
parB family (according to Swiss-Prot)
ParB family (with [[protein|Noc]], according to UniProt)
The protein
Structure
[PDB|4UMK] (complex with ''parS'' DNA)
[PDB|5U1G] [pubmed|28373206]
[PDB|5U1J] [pubmed|28373206]
[PDB|4UMK] (complex with ''parS'' DNA)
[PDB|5U1G] [pubmed|28373206]
[PDB|5U1J] [pubmed|28373206]
[PDB|6SDK] (complex with CDP)
References
Reviews
References
Original publications