2017-09-04 11:35:382025-05-13 10:44:18
description
ferrochelatase, catalyzes the final step of heme b biosynthesis
coproporphyrin ferrochelatase
locus
BSU10130
BSU_10130
geneLength
930
933
function
heme biosynthesis
biosynthesis of heme
product
ferrochelatase
coproporphyrin ferrochelatase
outlinks
bsu
BSU10130
BSU_10130
The protein
Catalyzed reaction/ biological activity
insertion of Fe(2+) into protoporphyrin IX
coproporphyrin --> coproheme [pubmed|25646457]
2 H+ + heme b --> Fe2+ + protoporphyrin IX (according to UniProt)
The protein
Protein family
ferrochelatase family (according to Swiss-Prot)
ferrochelatase family (with [[protein|YlnF]], according to UniProt)
The protein
Structure
[PDB|2HK6] (complex with iron), [PDB|1AK1]
[PDB|2HK6] (complex with iron) [pubmed|17198378]
[PDB|1AK1] [pubmed|9384565]
References
The protein
Paralogous protein(s)
[[this]]
Biological materials
Mutant
BKE10130 (Δ[[gene|hemH]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE10130 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTGTTTACACCCTCTTTA, downstream forward: _UP4_GGACGTTAAAGAAGGCGATG
BKK10130 (Δ[[gene|hemH]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK10130 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTGTTTACACCCTCTTTA, downstream forward: _UP4_GGACGTTAAAGAAGGCGATG
References
Reviews
References
Original Publications