2017-8-11 16:0:3Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)
description
primary bacitracin resistance determinant, ABC transporter (permease) for the export of bacitracin, plectasin, mersacidin and actagardine, sensory component of the Bce regulatory & detoxification system
ABC transporter (permease) for the export of bacitracin, plectasin, mersacidin and actagardine, sensory component of the Bce regulatory & detoxification system
proteinLength
646
geneLength
1938
Gene
Coordinates
3,109,397 → 3,111,337
Gene
Phenotypes of a mutant
85-fold increased sensitivity to bacitracin [Pubmed|26815905]
The protein
Effectors of protein activity
the activity of the [[protein|BceA]]-[[protein|BceB]] [SW|ABC transporter] is inhibited by heptaprenyl pyrophosphate which accumulates in a ''[[gene|ytpB]]'' mutant [Pubmed|24806199]
the activity of the [[protein|BceA]]-[[protein|BceB]] [SW|ABC transporter] is inhibited by heptaprenyl pyrophosphate which accumulates in a ''[[protein|ytpB]]'' mutant [Pubmed|24806199]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
MGNA-A168 (ytsD::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/168 NBRP B. subtilis, Japan]
References
Reviews
References
Original publications
aminos
MNINQLILRNLKKNLRNYYLYVFALIFSVALYFAFVTLQYDPAINEVKASIKGAAAIKTASILLVAVVAIFILYANTIFIKRRSKEIGLFQLIGMTKHKIFRILSAENVMLYFGSLAIGVAAGFSISKLVLMILFKIVDVKADAKLHFSEQALVQTVIVFCGIYLLIMIMNYTFIKKQSILSLFKVTSSTEDKVKKISFFQMLIGALGIVLILTGYYVSSELFGGKFKTINELFVAMSFILGSVIIGTFLFYKGSVTFISNIIRKSKGGYLNISEVLSLSSIMFRMKSNALLLTIITTVSALAIGLLSLAYISYYSSEKTAEQNVAADFSFMNEKDAKLFENKLRESNISFVKKATPVLQANVDIANIMDGTPKEMQGDPGNMQLAVVSDKDVKGVDVAAGEAVFSGYTDLLQKIMVFKDSGVIKVKSKHETQPLKYKGLREEFLVSYTFTSGGMPAVIVDDSLFKQLDKDKDPRIQLAQSTFIGVNVKHDDQMEKANELFQQVNKKNEHLSRLDTSAAQKSLFGMVMFIVGFLGLTFLITSGCILYFKQMGESEDEKPSYTILRKLGFTQGDLIKGIRIKQMYNFGIPLVVGLFHSYFAVQSGWFLFGSEVWAPMIMVMVLYTALYSIFGFLSVLYYKKVIKSSL
[SW|Categories] containing this gene/protein
[SW|ABC transporters], [SW|resistance against toxins/ antibiotics], [SW|membrane proteins]
Gene
Coordinates on the chromosome (coding sequence)
3,109,397 -> 3,111,337
The protein
[SW|Interactions]
[[protein|BceA]]-[[protein|BceB]] [Pubmed|25118291,23687272]
[[protein|BceB]]-[[protein|BceS]], in the absence of bacitracin [Pubmed|25118291,23687272,21283517]
Expression and Regulation
Operon
''[[protein|bceA]]-[[protein|bceB]]'' [Pubmed|12890034]
Expression and Regulation
Regulation
induced in the presence of bacitracin, plectasin, mersacidin and actagardine ([[protein|BceR]]) [Pubmed|12890034]
Expression and Regulation
Regulatory mechanism
[[protein|BceR]]: transcription activation [Pubmed|12890034]