Mon Aug 31 2015 13:57:02 GMT+0200 (CEST)2025-04-08 13:55:18
locus
BSU35170
BSU_35170
ec
outlinks
bsu
BSU35170
BSU_35170
syns
dinA, uvrA
[SW|Categories] containing this gene/protein
[SW|DNA repair/ recombination]
The protein
Protein family
uvrB family (according to Swiss-Prot)
UvrB family (with [[protein|Mfd]], according to UniProt)
The protein
[SW|Interactions]
[[protein|UvrA]]-[[protein|UvrB]] [Pubmed|16464004]
[[protein|UvrB]]-[[protein|UvrC]] [Pubmed|16464004]
[[protein|UvrB]] interacts sequentially with [[protein|UvrA]] and [[protein|UvrC]], a complex of the three proteins was never observed [Pubmed|16464004]
[[protein|UvrB]]-[[protein|PcrA]] [Pubmed|24147116]
Expression and Regulation
Operon
''[[protein|uvrB]]-[[protein|uvrA]]'' (according to [http://dbtbs.hgc.jp/COG/prom/uvrBA.html DBTBS])
Expression and Regulation
Regulation
induced upon DNA damage ([[protein|LexA]]) [Pubmed|8226626]
Expression and Regulation
Regulatory mechanism
[[protein|LexA]]: transcription repression [Pubmed|8226626]
Biological materials
Mutant
GP1175 (del ''uvrAB''::''ermC'') (available in the [SW|Stülke] lab)
GP3534 (Δ([[gene|uvrA]]-[[gene|uvrB]])::kan), available in [SW|Jörg Stülke]'s lab
GP1175 (Δ([[gene|uvrA]]-[[gene|uvrB]])::ermC), available in [SW|Jörg Stülke]'s lab [pubmed|22178973]
BKE35170 (Δ[[gene|uvrB]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE35170 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACAAAAATAAGCCTCCGTT, downstream forward: _UP4_CTAAAAGCGGAAGGATGATG
BKK35170 (Δ[[gene|uvrB]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK35170 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACAAAAATAAGCCTCCGTT, downstream forward: _UP4_CTAAAAGCGGAAGGATGATG
References
Original publications
proteinLength
661
geneLength
1986
Gene
Coordinates
3,612,945 → 3,614,930
Gene
Phenotypes of a mutant
a [[gene|uvrA]] [[gene|uvrB]] mutant is sensitive to blue light-induced DNA damage [pubmed|30054368]
reduced resistance towards electron beams [pubmed|31948638]
The protein
Paralogous protein(s)
[[this]]
The protein
[SW|Domains]
[SW|Helicase ATP-binding domain] (aa 26-413) (according to UniProt)
[SW|Helicase C-terminal domain] (aa 430-596) (according to UniProt)
[SW|UVR domain] (aa 625-660) (according to UniProt)
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]