SubtiBank SubtiBank
Version comparison:

Mon Aug 31 2015 13:57:02 GMT+0200 (CEST)2025-04-08 13:55:18

locus

BSU35170

BSU_35170

ec

outlinks

bsu

BSU35170

BSU_35170

syns

dinA, uvrA

[SW|Categories] containing this gene/protein

[SW|DNA repair/ recombination]

The protein

Protein family

uvrB family (according to Swiss-Prot)

UvrB family (with [[protein|Mfd]], according to UniProt)

The protein

[SW|Interactions]

[[protein|UvrA]]-[[protein|UvrB]] [Pubmed|16464004]

[[protein|UvrB]]-[[protein|UvrC]] [Pubmed|16464004]

[[protein|UvrB]] interacts sequentially with [[protein|UvrA]] and [[protein|UvrC]], a complex of the three proteins was never observed [Pubmed|16464004]

[[protein|UvrB]]-[[protein|PcrA]] [Pubmed|24147116]

Expression and Regulation

Operon

''[[protein|uvrB]]-[[protein|uvrA]]'' (according to [http://dbtbs.hgc.jp/COG/prom/uvrBA.html DBTBS])

Expression and Regulation

Regulation

induced upon DNA damage ([[protein|LexA]]) [Pubmed|8226626]

Expression and Regulation

Regulatory mechanism

[[protein|LexA]]: transcription repression [Pubmed|8226626]

Biological materials

Mutant

GP1175 (del ''uvrAB''::''ermC'') (available in the [SW|Stülke] lab)

GP3534 (Δ([[gene|uvrA]]-[[gene|uvrB]])::kan), available in [SW|Jörg Stülke]'s lab

GP1175 (Δ([[gene|uvrA]]-[[gene|uvrB]])::ermC), available in [SW|Jörg Stülke]'s lab [pubmed|22178973]

BKE35170 (Δ[[gene|uvrB]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE35170 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACAAAAATAAGCCTCCGTT, downstream forward: _UP4_CTAAAAGCGGAAGGATGATG

BKK35170 (Δ[[gene|uvrB]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK35170 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACAAAAATAAGCCTCCGTT, downstream forward: _UP4_CTAAAAGCGGAAGGATGATG

References

Original publications

8226626, 9555905, 16426634, 21821766, 24147116, 21145481, 25713353

8226626, 9555905, 16426634, 21821766, 24147116, 21145481, 25713353, 30054368, 31948638

proteinLength

661

geneLength

1986

Gene

Coordinates

3,612,945 → 3,614,930

Gene

Phenotypes of a mutant

a [[gene|uvrA]] [[gene|uvrB]] mutant is sensitive to blue light-induced DNA damage [pubmed|30054368]

reduced resistance towards electron beams [pubmed|31948638]

The protein

Paralogous protein(s)

[[this]]

The protein

[SW|Domains]

[SW|Helicase ATP-binding domain] (aa 26-413) (according to UniProt)

[SW|Helicase C-terminal domain] (aa 430-596) (according to UniProt)

[SW|UVR domain] (aa 625-660) (according to UniProt)

Expression and Regulation

Operons

[[this]]

Expression and Regulation

Other regulations

[[this]]