Mon May 16 2016 16:20:19 GMT+0200 (CEST)2025-05-25 01:48:29
locus
BSU06480
BSU_06480
outlinks
bsu
BSU06480
BSU_06480
[SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of nucleotides], [SW|membrane proteins], [SW|most abundant proteins]
Gene
Coordinates on the chromosome (coding sequence)
703,237 -> 705,465
The protein
Catalyzed reaction/ biological activity
ATP N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide L-glutamine H2O = ADP phosphate 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine L-glutamate (according to Swiss-Prot)
ATP + H2O + L-glutamine + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide --> 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + ADP + H+ + L-glutamate + phosphate(according to UniProt)
H2O + L-glutamine --> L-glutamate + NH4+ (according to UniProt)
The protein
Protein family
FGAMS family (according to Swiss-Prot)
FGAMS family (single member, according to UniProt)
The protein
[SW|Localization]
cytoplasm (according to Swiss-Prot), membrane associated [Pubmed|18763711]
cytoplasm (according to UniProt)
membrane associated [Pubmed|18763711]
The protein
[SW|Interactions]
[[protein|PurS]]-[[protein|PurQ]]-[[protein|PurL]] [Pubmed|15301530]
The protein
Additional information
:
subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids= 17981983 PubMed]
subject to Clp-dependent proteolysis upon glucose starvation [PubMed|17981983]
belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]
Expression and Regulation
Operon
''[[protein|purE]]-[[protein|purK]]-[[protein|purB]]-[[protein|purC]]-[[protein|purS]]-[[protein|purQ]]-[[protein|purL]]-[[protein|purF]]-[[protein|purM]]-[[protein|purN]]-[[protein|purH]]-[[protein|purD]]'' [Pubmed|3036807]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigA]] [Pubmed|3036807]
Expression and Regulation
Regulation
repressed in the presence of purine nucleotides ([[protein|PurR]]) [Pubmed|7638212]
repressed in the presence of adenine or adenosine([[protein|PurR]]) [Pubmed|2536750]
repressed in the presence of guanine([[protein|G-box]]) [Pubmed|3036807]
Expression and Regulation
Regulatory mechanism
[PurR]]: transcription repression [Pubmed|7638212]
[[protein|PurR]]: transcription repression (molecular inducer: PRPP) [Pubmed|2536750]
[[protein|G-box]]: transcription termination/ antitermination ([SW|riboswitch]) [http://www.ncbi.nlm.nih.gov/sites/entrez/3036807 PubMed1] [http://www.ncbi.nlm.nih.gov/sites/entrez/12787499 PubMed2]
Expression and Regulation
Additional information
subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids= 17981983 PubMed]
belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]
proteinLength
742
geneLength
2229
Gene
Coordinates
703,237 → 705,465
The protein
Paralogous protein(s)
[[this]]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
BKE06480 (Δ[[gene|purL]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE06480 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GTTCAAGCAGTAGTGACATG, downstream forward: _UP4_CCATGCTTGCTGAAATCAAA
BKK06480 (Δ[[gene|purL]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK06480 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GTTCAAGCAGTAGTGACATG, downstream forward: _UP4_CCATGCTTGCTGAAATCAAA