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mediates a developmental checkpoint couplinginitiation of sporulation (phosphorylation of Spo0A)to the function of replication initiation proteins

mediates a developmental checkpoint coupling
initiation of sporulation (phosphorylation of Spo0A)
to the function of replication initiation proteins

2,647,456 → 2,647,614

Sda is a checkpoint protein that is upregulated in response to replication stress [Pubmed|11207367]. Sda inhibits the autokinase activity of [[protein|KinA]] (and likely [[protein|KinB]] as well). This in its turn results in reduced levels of [[protein|Spo0A|Spo0A~P]]]]. Thus, replication stressed cells will not initiate sporulation.

Sda is a checkpoint protein that is upregulated in response to replication stress [Pubmed|11207367]. Sda inhibits the autokinase activity of [[protein|KinA]] (and likely [[protein|KinB]] as well). This in its turn results in reduced levels of [[Spo0A|Spo0A~P]]. Thus, replication stressed cells will not initiate sporulation.

[[protein|Sda]] is rapidly degraded by the [[protein|ClpP|ClpP/X]]]] system because of some uncharged residues at its C-terminus [Pubmed|16796683]

[[protein|Sda]] is rapidly degraded by the [[ClpP|ClpP/X]] system because of some uncharged residues at its C-terminus [Pubmed|16796683]

[[this]]

[[this]]

[SW|phosphorelay]

[[protein|KinB]]-[[protein|Sda]] [Pubmed|19465772]

[[protein|KinA]]-[[protein|Sda]] [Pubmed|15023339]

''[[protein|sda]]'' [Pubmed|11207367]

[[protein|SigA]] [Pubmed|11207367]

induced by DNA damage ([[protein|LexA]]) [Pubmed|16267290]

[[protein|DnaA]]: transcription activation under replication stress [Pubmed|17932079]

[[protein|LexA]]: transcription repression [Pubmed|16267290]