2017-05-24 16:11:10Wed Mar 30 2016 16:59:26 GMT+0200 (CEST)
proteinLength
197
geneLength
591
Gene
Coordinates
3,546,234 → 3,546,827
Gene
Phenotypes of a mutant
increased thermotolerance due to increased stabiliy of [[protein|Spx]] and thus increased expression of ''[[gene|trxA]]'' [Pubmed|24417481]
the mutation suppresses the heat sensitivity of spores overexpressing ''[[gene|cmpA]]'' [Pubmed|26387458]
non-motile [Pubmed|27014237]
increased thermotolerance due to increased stabiliy of [[protein|Spx]] and thus increased expression of ''[[protein|trxA]]'' [Pubmed|24417481]
the mutation suppresses the heat sensitivity of spores overexpressing ''[SW|cmpA]'' [Pubmed|26387458]
non-motile [Pubmed|27014237]
The protein
additional information
belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
''clpP::spec'' and ''clpP::cat'', available in the [SW|Leendert Hamoen] lab
BP99 (''clpP''::''tet''), available in [SW|Fabian Commichau]'s lab [Pubmed|25610436]
GP551 (spc), available in [SW|Jörg Stülke]'s lab
QB4916 (spc), available in [SW|Ulf Gerths]'s and [SW|Jörg Stülke]'s labs
1S139 (''clpP''::''erm''), available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S139&Search=1S139 BGSC]
1S140 ( ''clpP''::''spec''), available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S140&Search=1S140 BGSC]
BKE34540 (''[[gene|clpP]]''::''erm'', available in the BGSC and in [SW|Jörg Stülke]'s lab)
GP1822 and GP1786 (''[[gene|clpP]]''::''erm'', available in [SW|Jörg Stülke]'s lab)
GPUG1 (erm), available in [SW|Ulf Gerth]'s and [SW|Jörg Stülke]'s labs
''clpP::spec'' and ''clpP::cat'', available in the [SW|Leendert Hamoen] lab
BP99 (''clpP''::''tet''), available in [SW|Fabian Commichau]'s lab [Pubmed|25610436]
GP551 (spc), available in [SW|Jörg Stülke]'s lab
QB4916 (spc), available in [SW|Ulf Gerths]'s and [SW|Jörg Stülke]'s labs
1S139 (''clpP''::''erm''), available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S139&Search=1S139 BGSC]
1S140 ( ''clpP''::''spec''), available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S140&Search=1S140 BGSC]
BKE34540 (''[[protein|clpP]]''::''erm'', available in the BGSC and in [SW|Jörg Stülke]'s lab)
GP1822 (''[[protein|clpP]]''::''erm'', available in [SW|Jörg Stülke]'s lab)
GPUG1 (erm), available in [SW|Ulf Gerth]'s and [SW|Jörg Stülke]'s labs
References
Original Publications
[SW|Categories] containing this gene/protein
[SW|proteolysis], [SW|general stress proteins (controlled by SigB)], [SW|heat shock proteins], [SW|phosphoproteins], [SW|most abundant proteins]
Gene
Coordinates on the chromosome (coding sequence)
3,546,234 -> 3,546,827
The protein
[SW|Interactions]
forms a complex structure of two heptameric rings [Pubmed|26639779]
[[protein|ClpE]]-[[protein|ClpP]], [[protein|ClpC]]-[[protein|ClpP]], [[protein|ClpX]]-[[protein|ClpP]]
[[protein|CtsR]]-[[protein|ClpP]]/[[protein|ClpC]] (degradation of [[protein|CtsR]]) [Pubmed|11179229,16163393,17380125]
[[protein|McsB]]-[[protein|ClpP]]/[[protein|ClpC]] (rapid degradation of non-phosphorylated [[protein|McsB]]) [Pubmed|20852588]
[[protein|Spx]]-[[protein|ClpP]]/[[protein|ClpX]] (degradation of [[protein|Spx]]) [Pubmed|17827297]
Expression and Regulation
Operon
''clpP'' [Pubmed|9643546]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigA]] [Pubmed|9643546], [[protein|SigB]] [Pubmed|9643546,11544224]
Expression and Regulation
Regulation
induced by stress ([[protein|SigB]]) [Pubmed|9643546,11544224]
induced by heat ([[protein|CtsR]]) [Pubmed|9987115]
Expression and Regulation
Regulatory mechanism
[[protein|CtsR]]: transcription repression [Pubmed|9987115,11179229,16163393,17380125]
Expression and Regulation
Additional information
belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]