2017-8-11 16:0:32025-03-13 17:56:25
locus
BSU29100
BSU_29100
geneLength
1737
1740
ec
outlinks
bsu
BSU29100
BSU_29100
The protein
Catalyzed reaction/ biological activity
autophosphorylation, phosphorylation of [[protein|PhoP]]
autophosphorylation, phosphorylation of [[protein|PhoP]]
ATP + protein L-histidine --> ADP + protein N-phospho-L-histidine (according to UniProt)
The protein
[SW|Domains]
two transmembrane segments
[SW|PAS domain], for binding of an intermediate of wall teichoic acid biosynthesis [Pubmed|25315493]
C-terminal histidine phosphotransferase domain
two transmembrane segments
[SW|PAS domain], for binding of an intermediate of wall teichoic acid biosynthesis (lipid V composed of poly(glycerol phosphate)) [Pubmed|25315493]
[SW|Histidine kinase domain] (aa 357-575) (according to UniProt)
The protein
Effectors of protein activity
activity is inhibited by binding of an intermediate of wall teichoic acid biosynthesis to the intracellular [SW|PAS domain] of [[protein|PhoR]] [Pubmed|25315493]
activity is inhibited by binding of an intermediate of wall teichoic acid biosynthesis (lipid V composed of poly(glycerol phosphate) to the intracellular [SW|PAS domain] of [[protein|PhoR]] [Pubmed|25315493]
the kinase activity is activated by an intermediate in the WTA biosynthetic pathway (product of [[protein|TagA]] or [[protein|TagB]]) [pubmed|29644746]
Biological materials
Mutant
1A966 ( ''phoR''::''tet''), [Pubmed|14973033], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A966&Search=1A966 BGSC]
1A966 ( ''phoR''::''tet''), [Pubmed|14973033], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A966&Search=1A966 BGSC]
BKE29100 (Δ[[gene|phoR]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE29100 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TACAGAAAAAAGGCGCACAC, downstream forward: _UP4_TAATGTTTACAAAGGTTTAA
BKK29100 (Δ[[gene|phoR]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK29100 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TACAGAAAAAAGGCGCACAC, downstream forward: _UP4_TAATGTTTACAAAGGTTTAA
Labs working on this gene/protein
[SW|Marion Hulett], University of Illinois at Chicago, USA [http://www.uic.edu/depts/bios/faculty/hulett/hulettm.shtml Homepage]
References
Reviews
References
Original publications
The protein
Paralogous protein(s)
[[this]]
The protein
[SW|Localization]
cell membrane (according to UniProt)
labs
[SW|Marion Hulett], University of Illinois at Chicago, USA [http://www.uic.edu/depts/bios/faculty/hulett/hulettm.shtml Homepage]