Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)2025-05-31 12:23:59
locus
BSU14410
BSU_14410
ec
outlinks
subtilist
gene_detail+BG11977
gene_detail BG11977
outlinks
bsu
BSU14410
BSU_14410
syns
[SW|Categories] containing this gene/protein
[SW|protein secretion], [SW|membrane proteins]
Gene
Phenotypes of a mutant
a ''[[protein|sipS]] [[protein|sipT]]'' double mutant is not viable [Pubmed|9694797]
a ''[[gene|sipS]] [[gene|sipT]]'' double mutant is not viable [Pubmed|9694797]
The protein
Catalyzed reaction/ biological activity
Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins (according to Swiss-Prot)
Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins (according to UniProt)
The protein
Protein family
peptidase S26 family (according to Swiss-Prot)
[SW|peptidase S26 family] (according to UniProt)
The protein
Paralogous protein(s)
[[protein|SipS]], [[protein|SipU]], [[protein|SipV]]
[[this]]
The protein
[SW|Localization]
cell membrane (according to Swiss-Prot)
cell membrane (according to UniProt)
Expression and Regulation
Operon
''sipT'' [Pubmed|9694797]
Expression and Regulation
Regulatory mechanism
[[protein|DegU]]: transcription activation [Pubmed|9694797]
Labs working on this gene/protein
[SW|Jan Maarten van Dijl], Groningen, Netherlands
References
Reviews
References
Original publications
proteinLength
193
geneLength
582
Gene
Coordinates
1,511,308 → 1,511,889
The protein
Structure
[PDB|4NV4] (from B. anthracis, 44% identity)
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
BKE14410 (Δ[[gene|sipT]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE14410 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAAGTGTTTCCTCCTAGAC, downstream forward: _UP4_TAAAAACGCCTTGCTGGCCT
BKK14410 (Δ[[gene|sipT]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK14410 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAAGTGTTTCCTCCTAGAC, downstream forward: _UP4_TAAAAACGCCTTGCTGGCCT
labs
[SW|Jan Maarten van Dijl], Groningen, Netherlands