5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide L-glutamine = imidazole-glycerol phosphate 5-aminoimidazol-4-carboxamide ribonucleotide L-glutamate H₂O (according to Swiss-Prot)

5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-β-D-ribosyl)imidazole-4-carboxamide + L-glutamine --> 5-amino-1-(5-phospho-β-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H⁺ + L-glutamate (according to UniProt)