Tue Dec 13 2016 11:16:34 GMT+0100 (CET)2025-04-07 14:35:58
locus
BSU24620
BSU_24620
function
biofilm formation
[SW|biofilm formation]
ec
outlinks
bsu
BSU24620
BSU_24620
aminos
MGMKKKLSLGVASAALGLALVGGGTWAAFNDIKSKDATFASGTLDLSAKENSASVNLSNLKPGDKLTKDFQFENNGSLAIKEVLMALNYGDFKANGGSNTSPEDFLSQFEVTLLTVGKEGGNGYPKNIILDDANLKDLYLMSAKNDAAAAEKIKKQIDPKFLNASGKVNVATIDGKTAPEYDGVPKTPTDFDQVQMEIQFKDDKTKDEKGLMVQNKYQGNSIKLQFSFEATQWNGLTIKKDHTDKDGYVKENEKAHSEDKN
[SW|Categories] containing this gene/protein
[SW|biofilm formation]
Gene
Coordinates on the chromosome (coding sequence)
2,553,081 -> 2,553,866
Gene
Phenotypes of a mutant
altered cell death pattern in colonies [Pubmed|23012477]
altered cell death pattern in colonies [Pubmed|23012477]
increases membrane fluidity and cell death [pubmed|32313019]
The protein
Protein family
peptidase M73 family (according to Swiss-Prot)
peptidase M73 family (single member, according to UniProt)
The protein
[SW|Localization]
extracellular (signal peptide) [Pubmed|18957862], secretion requires [[protein|SipW]] [Pubmed|10049401]
membrane [Pubmed|18763711]
extracellular (signal peptide) [Pubmed|18957862], secretion requires [[protein|SipW]] [Pubmed|10049401]
The protein
[SW|Interactions]
forms fibers of variable length and 10-15 nm in width [Pubmed|20080671]
[[protein|TapA]]-[[protein|TasA]] [Pubmed|24488317]
[[protein|SipW]]-[[protein|TasA]] [Pubmed|10049401]
Expression and Regulation
Operon
''[[protein|tapA]]-[[protein|sipW]]-[[protein|tasA]]'' [Pubmed|16430695]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigA]] [Pubmed|16430695]
Expression and Regulation
Regulation
repressed by casamino acids [Pubmed|12107147]
repressed by [[protein|SinR]] [Pubmed|16430695]
repressed during logrithmic growth ([[protein|AbrB]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/10464223,17720793 PubMed]
Expression and Regulation
Regulatory mechanism
[[protein|AbrB]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/10464223,17720793 PubMed]
[[protein|SinR]]: transcription repression [Pubmed|16430695]
[[protein|RemA]]: transcription activation [Pubmed|23646920]
Expression and Regulation
Additional information
induction by sequestration of [[protein|SinR]] by [[protein|SinI]] or [[protein|SlrA]] [PubMed|15661000,19788541] or by SlrR [PubMed|20351052]
the '[[protein|tapA]]-[[protein|sipW]]-[[protein|tasA]]' operon is not expressed in a '[[protein|ymdB]]' mutant [PubMed|21856853]
the amount of the mRNA is substantially decreased upon depletion of [[Rny|RNase Y]] (this is likely due to the increased stability of the '[[protein|sinR]]' mRNA) [PubMed|21815947]
the mRNA is cleaved by [[protein|Rnc|RNase III]] [PubMed|26883633]
References
Reviews
References
Original publications
proteinLength
261
geneLength
786
Gene
Coordinates
2,553,081 → 2,553,866
The protein
Paralogous protein(s)
[[this]]
The protein
Structure
[PDB|5OF1] [pubmed|29531041]
[PDB|5OF2] [pubmed|29531041]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
MGNA-C449 (yqhF::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2447 NBRP B. subtilis, Japan]
BKE24620 (Δ[[gene|tasA]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE24620 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGGTAAGCTCCCCTTTTA, downstream forward: _UP4_TAATAACAGCAAAAAAAAGA
BKK24620 (Δ[[gene|tasA]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK24620 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGGTAAGCTCCCCTTTTA, downstream forward: _UP4_TAATAACAGCAAAAAAAAGA