Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)2025-05-24 11:16:32
description
resistance against oxidative stress and cell wall antibiotics, membrane anchor for LiaH
resistance against oxidative stress and cell wall antibiotics, membrane anchor for [[protein|LiaH]], secondary bacitracin resistance determinant
locus
BSU33130
BSU_33130
product
membrane anchor for LiaH
membrane anchor for [[protein|LiaH]]
ec
outlinks
bsu
BSU33130
BSU_33130
aminos
MKINKKTIGGFLLIVFGISVFFGGGSFGFIIPLAIGSLMTYAGIKRFAAGKTITGIIVGGIGAIMLICSLPFVVGIALAAAMVYYGWKLMKNGSADNGVSSFDPEPASAAYQSHFDDEWEEFLKKK
[SW|Categories] containing this gene/protein
[SW|resistance against oxidative and electrophile stress], [SW|resistance against toxins/ antibiotics], [SW|membrane proteins]
Gene
Coordinates on the chromosome (coding sequence)
3,398,550 -> 3,398,930
The protein
[SW|Interactions]
[[protein|LiaI]]-[[protein|LiaH]] [Pubmed|24666271]
Expression and Regulation
Operon
''[[protein|liaI]]-[[protein|liaH]]-[[protein|liaG]]-[[protein|liaF]]-[[protein|liaS]]-[[protein|liaR]]'' [Pubmed|14651641]
''[[protein|liaI]]-[[protein|liaH]]'' [Pubmed|20639339]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigA]] [Pubmed|15273097]
Expression and Regulation
Regulation
induced by bacitracin and rhamnolipids ([[protein|LiaR]]) [Pubmed|16816187,22092710]
repressed during logarithmic growth ([[protein|AbrB]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/15101989,17660417 PubMed], indirect regulation by [[protein|AbrB]] [Pubmed|20817675]
repressed by glucose (4.3-fold) [Pubmed|12850135]
Expression and Regulation
Regulatory mechanism
[[protein|LiaR]]: transcription activation [Pubmed|16816187]
Biological materials
Mutant
1A980 ( ''liaI''::''erm''), [Pubmed|15273097], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A980&Search=1A980 BGSC]
MGNA-B040 (yvqI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1039 NBRP B. subtilis, Japan]
1A980 ( ''liaI''::''erm''), [Pubmed|15273097], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A980&Search=1A980 BGSC]
BKE33130 (Δ[[gene|liaI]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE33130 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGCAGATCCTCCTTTCGT, downstream forward: _UP4_TAATATCAATATATTAGGAG
BKK33130 (Δ[[gene|liaI]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK33130 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGCAGATCCTCCTTTCGT, downstream forward: _UP4_TAATATCAATATATTAGGAG
References
Original publications
proteinLength
126
geneLength
381
Gene
Coordinates
3,398,550 → 3,398,930
The protein
Paralogous protein(s)
[[this]]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]