Tue Dec 13 2016 11:16:31 GMT+0100 (CET)2025-05-15 20:54:37
locus
BSU08630
BSU_08630
outlinks
bsu
BSU08630
BSU_08630
aminos
MNVLEDKLKQKDIQQFRDDLISWFEREQRVLPWREDQDPYKVWVSEVMLQQTRVETVIPYFLRFVEQFPTVEALADADEEKVLKAWEGLGYYSRVRNLQSAVKEVKQEYGGIVPPDEKDFGGLKGVGPYTKGAVLSIAYNKPIPAVDGNVMRVMSRILSIWDDIAKPKTRTIFEDAIRAFISKEKPSEFNQGLMELGALICTPKSPSCLLCPVQQHCSAFEEGTERELPVKSKKKKPGIKTMAAIVLTDEDGQVYIHKRPSKGLLANLWEFPNLETQKGIKTEREQLIAFLENEYGIQADISDLQGVVEHVFTHLVWNISVFFGKVKQVSDTSKLKKVTKEELEQFAFPVSHQKIWKMAGEAAAISAAP
[SW|Categories] containing this gene/protein
[SW|DNA repair/ recombination]
Gene
Coordinates on the chromosome (coding sequence)
935,656 -> 936,765
The protein
Catalyzed reaction/ biological activity
releases adenines from 8-oxo-G:A mismatches
releases adenines from 8-oxo-G:A mismatches
Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site (according to UniProt)
Expression and Regulation
Operon
''[[protein|mutY]]-[[protein|fabL]]-[[protein|sspE]]'' [Pubmed|10463184]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigA]] [Pubmed|10463184]
[[protein|SigG]] [Pubmed|1900507]
Expression and Regulation
Regulation
expression is constitutive throughout growth [Pubmed|20971907]
expression is fivefold increased in a ''[[protein|mutS]]-[[protein|mutL]]'' mutant [Pubmed|20971907]
[[protein|YfhP]] may act as a negative transcription regulator of the ''[[protein|mutY]]-[[protein|fabL]]-[[protein|sspE]]'' operon during exponential growth [Pubmed|10463184]
References
Original publications
proteinLength
369
geneLength
1110
Gene
Coordinates
935,656 → 936,765
The protein
Protein family
Nth/MutY family (with [[protein|Nth]], according to UniProt)
The protein
Paralogous protein(s)
[[this]]
The protein
[SW|Domains]
HhH domain (aa 108-137) (according to UniProt)
The protein
[SW|Cofactors]
Fe-S cluster [pubmed|29292548]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
MGNA-C322 (yfhQ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2320 NBRP B. subtilis, Japan]
BKE08630 (Δ[[gene|mutY]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE08630 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATGTGTTTCTCCCCAGT, downstream forward: _UP4_ATCTCGGCTGCTCCGTAAAC
BKK08630 (Δ[[gene|mutY]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK08630 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATGTGTTTCTCCCCAGT, downstream forward: _UP4_ATCTCGGCTGCTCCGTAAAC