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Thu Aug 18 2016 18:38:33 GMT+0200 (CEST)2025-05-18 18:00:31

description

SEDS family peptidoglycan glycosyltransferase, control of cell shape and elongation

SEDS family peptidoglycan glycosyltransferase, part of the [[protein|Rod complex]] for lateral [SW|cell wall synthesis] and control of cell diameter

locus

BSU38120

BSU_38120

ec

outlinks

bsu

BSU38120

BSU_38120

[SW|Categories] containing this gene/protein

[SW|cell shape], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)], [SW|essential genes], [SW|membrane proteins]

Gene

Coordinates on the chromosome (coding sequence)

3,912,332 -> 3,913,513

The protein

Catalyzed reaction/ biological activity

principal peptidoglycan glycosyltransferase of the [SW|elongasome] [Pubmed|27525505]

principal peptidoglycan glycosyltransferase of the [SW|elongasome] [Pubmed|27525505]

[GlcNAc-(1→4)-Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphospho-di-trans,octa-cis-undecaprenol + β-D-GlcNAc-(1→4)-Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol --> [GlcNAc-(1→4)-Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphospho-di-trans-octa-cis-undecaprenol + di-trans,octa-cis-undecaprenyl diphosphate + H+ (according to UniProt)

The protein

Protein family

[SW|FtsW]/[SW|RodA]/[SW|SpoVE] family (according to Swiss-Prot)

[SW|SEDS proteins] (shape, elongation, division, and sporulation) [Pubmed|27525505]

[SW|SEDS proteins] (shape, elongation, division, and sporulation) [Pubmed|27525505]

SEDS family (with [[protein|FtsW]] and [[protein|SpoVE]], according to UniProt)

The protein

Paralogous protein(s)

[[protein|FtsW]], [SW|SpoVE]

[[this]]

The protein

[SW|Localization]

integral membrane protein [Pubmed|21636744]

forms circumferentially moving patches [Pubmed|21636744]

localization depends on [SW|MreB] [SW|26679002]

integral membrane protein [Pubmed|21636744]

forms circumferentially moving patches [Pubmed|21636744]

localization depends on [[protein|MreB]] [SW|26679002]

The protein

[SW|Interactions]

part of the [SW|elongasome] [Pubmed|21636744,21636745]

Expression and Regulation

Operon

''rodA'' [Pubmed|9353933]

Expression and Regulation

[SW|Sigma factor]

[[protein|SigM]] [http://www.ncbi.nlm.nih.gov/sites/entrez/18179421 Pubmed]

Labs working on this gene/protein

[SW|Charles Moran], Emory University, NC, USA [http://www.microbiology.emory.edu/moran_c.html homepage]

[SW|David Rudner], Harvard Medical School, MA, USA [http://rudnerlab.med.harvard.edu/ homepage]

References

Reviews

26679002

26679002, 28975672

References

Original Publications

27525505, 27238023, 9622350, 21636744, 21636745, 17981970

27525505, 27238023, 9622350, 21636744, 21636745, 17981970, 28085152, 29590088, 31086310, 32152588, 32973704

proteinLength

393

geneLength

1182

Gene

Coordinates

3,912,332 → 3,913,513

The protein

Structure

[PDB|6BAR] (from Thermus thermophilus, 26% identity) [pubmed|29590088]

Expression and Regulation

Operons

[[this]]

Expression and Regulation

Other regulations

[[this]]

labs

[SW|Charles Moran], Emory University, NC, USA [http://www.microbiology.emory.edu/moran_c.html homepage]

[SW|David Rudner], Harvard Medical School, MA, USA [http://rudnerlab.med.harvard.edu/ homepage]