Thu Aug 18 2016 18:38:33 GMT+0200 (CEST)2025-05-18 18:00:31
description
SEDS family peptidoglycan glycosyltransferase, control of cell shape and elongation
SEDS family peptidoglycan glycosyltransferase, part of the [[protein|Rod complex]] for lateral [SW|cell wall synthesis] and control of cell diameter
locus
BSU38120
BSU_38120
ec
outlinks
bsu
BSU38120
BSU_38120
[SW|Categories] containing this gene/protein
[SW|cell shape], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)], [SW|essential genes], [SW|membrane proteins]
Gene
Coordinates on the chromosome (coding sequence)
3,912,332 -> 3,913,513
The protein
Catalyzed reaction/ biological activity
principal peptidoglycan glycosyltransferase of the [SW|elongasome] [Pubmed|27525505]
principal peptidoglycan glycosyltransferase of the [SW|elongasome] [Pubmed|27525505]
[GlcNAc-(1→4)-Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphospho-di-trans,octa-cis-undecaprenol + β-D-GlcNAc-(1→4)-Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol --> [GlcNAc-(1→4)-Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphospho-di-trans-octa-cis-undecaprenol + di-trans,octa-cis-undecaprenyl diphosphate + H+ (according to UniProt)
The protein
Protein family
[SW|FtsW]/[SW|RodA]/[SW|SpoVE] family (according to Swiss-Prot)
[SW|SEDS proteins] (shape, elongation, division, and sporulation) [Pubmed|27525505]
[SW|SEDS proteins] (shape, elongation, division, and sporulation) [Pubmed|27525505]
SEDS family (with [[protein|FtsW]] and [[protein|SpoVE]], according to UniProt)
The protein
Paralogous protein(s)
[[protein|FtsW]], [SW|SpoVE]
[[this]]
The protein
[SW|Localization]
integral membrane protein [Pubmed|21636744]
forms circumferentially moving patches [Pubmed|21636744]
localization depends on [SW|MreB] [SW|26679002]
integral membrane protein [Pubmed|21636744]
forms circumferentially moving patches [Pubmed|21636744]
localization depends on [[protein|MreB]] [SW|26679002]
The protein
[SW|Interactions]
part of the [SW|elongasome] [Pubmed|21636744,21636745]
Expression and Regulation
Operon
''rodA'' [Pubmed|9353933]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigM]] [http://www.ncbi.nlm.nih.gov/sites/entrez/18179421 Pubmed]
Labs working on this gene/protein
[SW|Charles Moran], Emory University, NC, USA [http://www.microbiology.emory.edu/moran_c.html homepage]
[SW|David Rudner], Harvard Medical School, MA, USA [http://rudnerlab.med.harvard.edu/ homepage]
References
Reviews
References
Original Publications
proteinLength
393
geneLength
1182
Gene
Coordinates
3,912,332 → 3,913,513
The protein
Structure
[PDB|6BAR] (from Thermus thermophilus, 26% identity) [pubmed|29590088]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
labs
[SW|Charles Moran], Emory University, NC, USA [http://www.microbiology.emory.edu/moran_c.html homepage]
[SW|David Rudner], Harvard Medical School, MA, USA [http://rudnerlab.med.harvard.edu/ homepage]