2017-8-11 16:0:32025-05-30 13:49:32
locus
BSU13410
BSU_13410
geneLength
933
936
ec
outlinks
bsu
BSU13410
BSU_13410
Gene
Phenotypes of a mutant
sensitivity to ionizing radiation in the stationary phase [Pubmed|12215643]
sensitivity of spores to several DNA-damaging treatments known to cause double strand breaks, such as UV-ray, X-ray, ultrahigh vacuum and wet heat [Pubmed|16497325,17293412]
a ''[[gene|ykoV]]-[[gene|ligD]]'' double mutant is sensitive to radiation [Pubmed|24123749]
sensitivity to ionizing radiation in the stationary phase [Pubmed|12215643]
sensitivity of spores to several DNA-damaging treatments known to cause double strand breaks, such as UV-ray, X-ray, ultrahigh vacuum and wet heat [Pubmed|16497325,17293412]
a ''[[gene|ykoV]]-[[gene|ligD]]'' double mutant is sensitive to radiation [Pubmed|24123749]
reduced resistance towards electron beams [pubmed|31948638]
The protein
Catalyzed reaction/ biological activity
stimulation of [[protein|LigD]] non-homologous end-joining activity [Pubmed|23691176,26961308]
stimulation of [[protein|LigD]] non-homologous end-joining activity [Pubmed|23691176,26961308]
binds at the DNA double-strand breaks and recruits the ligase [[protein|LigD ]]to seal the break [pubmed|15778718,16518468]
Biological materials
Mutant
MGNA-A779 (ykoV::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/779 NBRP B. subtilis, Japan]
BP141 (''[[gene|ykoV]]-[[gene|ligD]]''::''kan'') available in [SW|Fabian Commichau]'s lab
BP142 (''[[gene|dgcW]]-[[gene|ykoV]]-[[gene|ligD]]''::''kan'') available in [SW|Fabian Commichau]'s lab
MGNA-A779 (ykoV::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/779 NBRP B. subtilis, Japan]
BP809 (Δ[[gene|ykoV]]::''cat'') available in [SW|Juan Alonso]'s and [SW|Jörg Stülke]'s labs [pubmed|16780573]
BP141 (Δ''[[gene|ykoV]]-[[gene|ligD]]''::''kan'') available in [SW|Fabian Commichau]'s and [SW|Jörg Stülke]'s labs [pubmed|30863384]
BP142 (Δ''[[gene|dgcW]]-[[gene|ykoV]]-[[gene|ligD]]''::''kan'') available in [SW|Fabian Commichau]'s lab
BKE13410 (Δ[[gene|ykoV]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE13410 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTGTAGTAACTTATGGG, downstream forward: _UP4_AAAGCCTCCGGCACATCATA
BKK13410 (Δ[[gene|ykoV]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK13410 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTGTAGTAACTTATGGG, downstream forward: _UP4_AAAGCCTCCGGCACATCATA
References
Reviews
References
Original publications
The protein
Protein family
prokaryotic Ku family (single member, according to UniProt)
The protein
Paralogous protein(s)
[[this]]
The protein
[SW|Domains]
KU domain (aa 26-210) (according to UniProt)