Tue Dec 13 2016 11:16:35 GMT+0100 (CET)2025-05-30 02:53:45
description
negative regulator of FtsZ ring formation
negative regulator of [[protein|FtsZ ]]ring formation
locus
BSU29610
BSU_29610
function
control of FtsZ ring formation
control of [[protein|FtsZ ]]ring formation
product
FtsZ-interacting protein
[[protein|FtsZ]]-interacting protein, member of the [SW|divisome]
ec
outlinks
bsu
BSU29610
BSU_29610
aminos
MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSIVEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKANQVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHLYGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKLLADCKQTVPGQIAKLKDGYGEMKEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDIDEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHTKAETELVKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIEEVKKEHAEYRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLENAHHHIQETVNQLNELPLNMEEAGAHLKQAEDIVNRASRESEELVEQVILIEKIIQFGNRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADISA
[SW|Categories] containing this gene/protein
[SW|cell division], [SW|membrane proteins]
Gene
Coordinates on the chromosome (coding sequence)
3,029,729 -> 3,031,417
Gene
Phenotypes of a mutant
altered localization of [[protein|FtsZ]] and [[ponA|PBP1]] [Pubmed|25403286]
growth defects, elongated cells [Pubmed|25403286]
the ''[[protein|ezrA]]'' mutation is synthetically lethal with a ''[[protein|sepF]]'' mutation [Pubmed|24218584]
a ''[[protein|yvcL]] [[protein|ezrA]]'' double mutant grows poorly, and the cells are filamentous [Pubmed|24097947]
a ''[[protein|zapA]] [[protein|ezrA]]'' double mutant forms filamentous cells [Pubmed|16420366]
depletion of ''[[protein|pdhA]]'' and deletion of ''[[protein|ezrA]]'' have a strong synthetic defect in [SW|cell division] [Pubmed|24825009]
altered localization of [[protein|FtsZ]] and [[gene|ponA|PBP1]]]] [Pubmed|25403286]
growth defects, elongated cells [Pubmed|25403286]
the ''[[gene|ezrA]]'' mutation is synthetically lethal with a ''[[gene|sepF]]'' mutation [Pubmed|24218584]
a ''[[gene|whiA]] [[gene|ezrA]]'' double mutant grows poorly, and the cells are filamentous [Pubmed|24097947]
a ''[[gene|zapA]] [[gene|ezrA]]'' double mutant forms filamentous cells [Pubmed|16420366]
depletion of ''[[gene|pdhA]]'' and deletion of ''[[gene|ezrA]]'' have a strong synthetic defect in [SW|cell division] [Pubmed|24825009]
The protein
Catalyzed reaction/ biological activity
inhibits [[protein|FtsZ]] polymerization [Pubmed|25403286]
recruits [[ponA|PBP1]] to the division septum [Pubmed|25403286]
activates [[protein|PrkC]] [Pubmed|25845974]
inhibits [[protein|FtsZ]] polymerization [Pubmed|25403286]
recruits [[gene|ponA|PBP1]]]] to the division septum [Pubmed|25403286]
activates [[protein|PrkC]] [Pubmed|25845974]
The protein
Protein family
ezrA family (according to Swiss-Prot)
EzrA family (single member, according to UniProt)
The protein
[SW|Localization]
membrane associated [Pubmed|18763711]
1 transmembrane domain at the N-terminus [Pubmed|25403286]
cell membrane (integral) [Pubmed|10449747]
1 transmembrane domain at the N-terminus [Pubmed|25403286]
The protein
[SW|Interactions]
[[protein|EzrA]]-[[protein|UgtP]] [Pubmed|17662947]
[[protein|FtsZ]]-[[protein|EzrA]] [Pubmed|25403286,10449747]
[[protein|EzrA]]-[[protein|GpsB]] [Pubmed|18363795]
[[protein|EzrA]]-[[protein|PonA]] [Pubmed|18363795]
Expression and Regulation
Operon
''[[protein|ezrA]]'' [Pubmed|9387221]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigA]] [Pubmed|15317798]
Expression and Regulation
Regulation
constitutively expressed [Pubmed|23701187]
Expression and Regulation
Additional information
degradation of [[protein|EzrA]] involves [[protein|FtsH]] [PubMed|24222488]
Biological materials
Mutant
1A805 ( ''ezrA''::''kan''), [Pubmed|15101985], available at [http://bgsc.org BGSC]
1A1279 (''ezrA''::''spec''), [Pubmed|10449747], available at [http://bgsc.org BGSC]
1A1280 (''ezrA-gfp''), [Pubmed|10449747], available at [http://bgsc.org BGSC]
MGNA-A428 (ytwP::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/428 NBRP B. subtilis, Japan]
1A805 ( ''ezrA''::''kan''), [Pubmed|15101985], available at [http://bgsc.org BGSC]
1A1279 (''ezrA''::''spec''), [Pubmed|10449747], available at [http://bgsc.org BGSC]
1A1280 (''ezrA-gfp''), [Pubmed|10449747], available at [http://bgsc.org BGSC]
BKE29610 (Δ[[gene|ezrA]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE29610 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAATGAGCCCCCTTGCTG, downstream forward: _UP4_TAGATAATCACGACCATGAA
BKK29610 (Δ[[gene|ezrA]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK29610 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAATGAGCCCCCTTGCTG, downstream forward: _UP4_TAGATAATCACGACCATGAA
References
Reviews
References
Original Publications
proteinLength
562
geneLength
1689
Gene
Coordinates
3,029,729 → 3,031,417
The protein
Paralogous protein(s)
[[this]]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]