SubtiBank SubtiBank
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Tue Dec 13 2016 11:16:35 GMT+0100 (CET)2025-05-12 05:05:06

description

cystine ABC transporter (permease)

cystine [SW|ABC transporter] (permease)

locus

BSU29350

BSU_29350

product

cystine ABC transporter (permease)

cystine [SW|ABC transporter] (permease)

ec

outlinks

bsu

BSU29350

BSU_29350

aminos

MQFDFPFIVSAMKEMVKTIPLTLMMAVLPIVFGFLVALGNIIVRIFRIKGLVACSRFYVSFFRSTPAILHIMLIYLGIPPVADQVSSFFHLGWSANEIPVSMFVIMALSLTAGAYLTEIIRSGILAMDTGQVEAAYSIGLTYSQTFRRVILPQALKVSIPNFTNLGIGFLHTTSIAAIVAVPEITGTATIVASDNYAFLEAFIGAAIIYWVLTLILESANGVLERKAARFQGGTL

[SW|Categories] containing this gene/protein

[SW|ABC transporters], [SW|biosynthesis/ acquisition of amino acids], [SW|membrane proteins]

Gene

Coordinates on the chromosome (coding sequence)

3,005,122 -> 3,005,829

The protein

Protein family

binding-protein-dependent transport system permease family (according to Swiss-Prot)

[SW|Binding-protein-dependent transport system permease family] (according to UniProt)

The protein

[SW|Interactions]

[[protein|TcyN]]-([[protein|TcyL]]-[[protein|TcyM]])-([[protein|TcyJ]]-[[protein|TcyK]]) [Pubmed|10092453]

Expression and Regulation

Operon

''[[protein|snaA]]-[[protein|tcyJ]]-[[protein|tcyK]]-[[protein|tcyL]]-[[protein|tcyM]]-[[protein|tcyN]]-[[protein|cmoO]]-[[protein|cmoI]]-[[protein|cmoJ]]-[[protein|ribR]]-[[protein|sndA]]-[[protein|ytnM]]'' [Pubmed|15668000]

Expression and Regulation

[SW|Sigma factor]

[[protein|SigA]] [Pubmed|15272571]

Expression and Regulation

Regulation

repressed in the presence of cysteine ([[protein|CymR]]) [Pubmed|16109943]

induced in the presence of S-methyl-cysteine ([[protein|AscR]]) [Pubmed|23944997]

Expression and Regulation

Regulatory mechanism

[[protein|CymR]]: transcription repression [Pubmed|16109943]

[[protein|AscR]]: transcription activation [Pubmed|16109943]

Biological materials

Mutant

1A948 ( ''tcyM''::''kan''), [Pubmed|15262924], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A948&Search=1A948 BGSC]

MGNA-A173 (ytmM::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/173 NBRP B. subtilis, Japan]

1A948 ( ''tcyM''::''kan''), [Pubmed|15262924], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A948&Search=1A948 BGSC]

BKE29350 (Δ[[gene|tcyM]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE29350 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATCTTCTCCCCCCTCATC, downstream forward: _UP4_GCCAGATTTCAAGGAGGCAC

BKK29350 (Δ[[gene|tcyM]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK29350 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATCTTCTCCCCCCTCATC, downstream forward: _UP4_GCCAGATTTCAAGGAGGCAC

References

15262924, 10092453, 16109943, 12193636, 15668000, 15272571, 23944997

15262924, 10092453, 16109943, 12193636, 15668000, 15272571, 23944997, 25848002

proteinLength

235

geneLength

708

Gene

Coordinates

3,005,122 → 3,005,829

The protein

Paralogous protein(s)

[[this]]

The protein

[SW|Domains]

[SW|ABC transmembrane type-1 domain] (aa 15-220) (according to UniProt)

The protein

Structure

[PDB|4YMS] (amino acid transporter from Caldanaerobacter subterraneus, 31% identity) [pubmed|25848002]

Expression and Regulation

Operons

[[this]]

Expression and Regulation

Other regulations

[[this]]