Tue Dec 13 2016 11:16:35 GMT+0100 (CET)2025-05-12 05:05:06
description
cystine ABC transporter (permease)
cystine [SW|ABC transporter] (permease)
locus
BSU29350
BSU_29350
product
cystine ABC transporter (permease)
cystine [SW|ABC transporter] (permease)
ec
outlinks
bsu
BSU29350
BSU_29350
aminos
MQFDFPFIVSAMKEMVKTIPLTLMMAVLPIVFGFLVALGNIIVRIFRIKGLVACSRFYVSFFRSTPAILHIMLIYLGIPPVADQVSSFFHLGWSANEIPVSMFVIMALSLTAGAYLTEIIRSGILAMDTGQVEAAYSIGLTYSQTFRRVILPQALKVSIPNFTNLGIGFLHTTSIAAIVAVPEITGTATIVASDNYAFLEAFIGAAIIYWVLTLILESANGVLERKAARFQGGTL
[SW|Categories] containing this gene/protein
[SW|ABC transporters], [SW|biosynthesis/ acquisition of amino acids], [SW|membrane proteins]
Gene
Coordinates on the chromosome (coding sequence)
3,005,122 -> 3,005,829
The protein
Protein family
binding-protein-dependent transport system permease family (according to Swiss-Prot)
[SW|Binding-protein-dependent transport system permease family] (according to UniProt)
The protein
[SW|Interactions]
[[protein|TcyN]]-([[protein|TcyL]]-[[protein|TcyM]])-([[protein|TcyJ]]-[[protein|TcyK]]) [Pubmed|10092453]
Expression and Regulation
Operon
''[[protein|snaA]]-[[protein|tcyJ]]-[[protein|tcyK]]-[[protein|tcyL]]-[[protein|tcyM]]-[[protein|tcyN]]-[[protein|cmoO]]-[[protein|cmoI]]-[[protein|cmoJ]]-[[protein|ribR]]-[[protein|sndA]]-[[protein|ytnM]]'' [Pubmed|15668000]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigA]] [Pubmed|15272571]
Expression and Regulation
Regulation
repressed in the presence of cysteine ([[protein|CymR]]) [Pubmed|16109943]
induced in the presence of S-methyl-cysteine ([[protein|AscR]]) [Pubmed|23944997]
Expression and Regulation
Regulatory mechanism
[[protein|CymR]]: transcription repression [Pubmed|16109943]
[[protein|AscR]]: transcription activation [Pubmed|16109943]
Biological materials
Mutant
1A948 ( ''tcyM''::''kan''), [Pubmed|15262924], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A948&Search=1A948 BGSC]
MGNA-A173 (ytmM::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/173 NBRP B. subtilis, Japan]
1A948 ( ''tcyM''::''kan''), [Pubmed|15262924], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A948&Search=1A948 BGSC]
BKE29350 (Δ[[gene|tcyM]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE29350 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATCTTCTCCCCCCTCATC, downstream forward: _UP4_GCCAGATTTCAAGGAGGCAC
BKK29350 (Δ[[gene|tcyM]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK29350 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATCTTCTCCCCCCTCATC, downstream forward: _UP4_GCCAGATTTCAAGGAGGCAC
References
proteinLength
235
geneLength
708
Gene
Coordinates
3,005,122 → 3,005,829
The protein
Paralogous protein(s)
[[this]]
The protein
[SW|Domains]
[SW|ABC transmembrane type-1 domain] (aa 15-220) (according to UniProt)
The protein
Structure
[PDB|4YMS] (amino acid transporter from Caldanaerobacter subterraneus, 31% identity) [pubmed|25848002]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]