2017-05-24 16:10:52Tue Dec 13 2016 11:16:37 GMT+0100 (CET)
description
undecaprenyl pyrophosphate phosphatase, produces the carrier lipid for cell wall synthesis, secondary bacitracin resistance determinant
undecaprenyl pyrophosphate phosphatase, produces the carrier lipid for cell wall synthesis, bacitracin resistance
proteinLength
193
geneLength
579
Gene
Coordinates
3,758,547 → 3,759,128
Gene
Phenotypes of a mutant
5-fold increased sensitivity to bacitracin [Pubmed|26815905]
reduced growth rate [Pubmed|26815905]
increased susceptibility to rare earth elements [Pubmed|22904278]
a ''[[gene|bcrC]]'' ''[[gene|uppP]]'' double mutant is not viable (unless ''[[gene|pgpB]]'' is artificially expressed) [Pubmed|27528508]
increased susceptibility to rare earth elements [Pubmed|22904278]
a ''[SW|bcrC]'' ''[SW|uppP]'' double mutant is not viable (unless ''[SW|yodM]'' is artificially expressed) [Pubmed|27528508]
The protein
Catalyzed reaction/ biological activity
undecaprenyl pyrophosphate -→ undecaprenyl phosphate
undecaprenyl pyrophosphate --> undecaprenyl phosphate
The protein
Effectors of protein activity
inhibited by heptaprenyl pyrophosphate which accumulates in a ''[[gene|ytpB]]'' mutant [Pubmed|24806199]
inhibited by heptaprenyl pyrophosphate which accumulates in a ''[[protein|ytpB]]'' mutant [Pubmed|24806199]
The protein
Additional information
there is a second undecaprenyl pyrophosphate phosphatase in ''B. subtilis'', [[protein|UppP]]. However, [[protein|UppP]] seems to play only a minor role. [Pubmed|22904278]
there is a second undecaprenyl pyrophosphate phosphatase in ''B. subtilis'', [[protein|YubB]]. However, [[protein|YubB]] seems to play only a minor role. [Pubmed|22904278]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
References
Original publications
[SW|Categories] containing this gene/protein
[SW|cell wall synthesis], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)], [SW|heat shock proteins], [SW|resistance against toxins/ antibiotics], [SW|membrane proteins]
Gene
Coordinates on the chromosome (coding sequence)
3,758,547 -> 3,759,128
Expression and Regulation
Operon
''bcrC
Expression and Regulation
[SW|Sigma factor]
[[protein|SigM]] [Pubmed|17434969], [[protein|SigI]] [Pubmed|18156261], [[protein|SigW]] [Pubmed|11866510], [[protein|SigX]] [Pubmed|12399481]
Expression and Regulation
Regulation
expression activated by glucose (3.3 fold) [Pubmed|12850135]
induced by heat shock ([[protein|SigI]]) [Pubmed|18156261]
induced by bacitracin
induced by oxidative stress
induced in the stationary phase due to the internal production of toxic peptides ([SW|SdpC], [SW|SkfA]) [Pubmed|26364265]
expression is reduced in a [[protein|SigV]] mutant [Pubmed|21926231]