Tue Dec 13 2016 11:16:37 GMT+0100 (CET)2025-06-02 02:47:47
locus
BSU37690
BSU_37690
product
aminotransferase
pyridoxal 5-phosphate-dependent stereospecific aminotransferase
outlinks
bsu
BSU37690
BSU_37690
aminos
MEITPSDVIKTLPRQEFSLVFQKVKEMEKTGAHIINLGQGNPDLPTPPHIVEALREASLNPSFHGYGPFRGYPFLKEAIAAFYKREYGVTINPETEVALFGGGKAGLYVLTQCLLNPGDIALVPNPGYPEYLSGITMARAELYEMPLYEENGYLPDFEKIDPAVLEKAKLMFLNYPNNPTGAVADAAFYAKAAAFAKEHNIHLIHDFAYGAFEFDQKPASFLEAEDAKTVGAELYSFSKTFNMAGWRMAFAVGNEKIIQAVNEFQDHVFVGMFGGLQQAASAALSGDPEHTESLKRIYKERIDFFTALCEKELGWKMEKPKGTFYVWAEIPNTFETSHQFSDYLLEHAHVVVTPGEIFGSNGKRHVRISMVSKQEDLREFVTRIQKLNLPFGSLQETSR
[SW|Categories] containing this gene/protein
[SW|miscellaneous metabolic pathways], [SW|biosynthesis of antibacterial compounds]
Gene
Coordinates on the chromosome (coding sequence)
3,868,287 -> 3,869,486
The protein
Protein family
class-I pyridoxal-phosphate-dependent aminotransferase family (according to Swiss-Prot)
[SW|class-I pyridoxal-phosphate-dependent aminotransferase family] (according to UniProt)
Expression and Regulation
Operon
''[[protein|bacA]]-[[protein|bacB]]-[[protein|bacC]]-[[protein|bacD]]-[[protein|bacE]]-[[protein|bacF]]'' [Pubmed|12372825]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigA]] [Pubmed|19801406]
Expression and Regulation
Regulatory mechanism
[[protein|CodY]]: transcription repression [Pubmed|12372825,21709425]
[[protein|AbrB]]: transcription repression [Pubmed|12697329,21709425]
[[protein|ScoC]]: transcription repression [Pubmed|19801406]
References
proteinLength
399
geneLength
1200
Gene
Coordinates
3,868,287 3,869,486
The protein
Paralogous protein(s)
[[this]]
The protein
[SW|Cofactors]
PLP
The protein
Structure
[PDB|6L1L] (apo-protein) [pubmed|32134000]
[PDB|6L1N] (substrate-bound) [pubmed|32134000]
[PDB|6L1O] (product-bound) [pubmed|32134000]
[PDB|2O1B] (from Staphylococcus aureus, 40% identity)
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
MGNA-A514 (ywfG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/514 NBRP B. subtilis, Japan]
BKE37690 ([[gene|bacF]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE37690 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GACATCGGACGGTGTTATTT, downstream forward: _UP4_TCCCGCTAAAAAGCGGGATG
BKK37690 ([[gene|bacF]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK37690 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GACATCGGACGGTGTTATTT, downstream forward: _UP4_TCCCGCTAAAAAGCGGGATG