Mon Aug 31 2015 13:54:04 GMT+0200 (CEST)2025-05-22 13:00:15
description
fructose-specific phosphotransferase system, EIIABC of the PTS
fructose-specific permease of the [SW|phosphotransferase systems|phosphotransferase system], EIIABC of the [[category|Phosphotransferase system|PTS]]
locus
BSU14400
BSU_14400
product
fructose-specific phosphotransferase system, EIIABC
fructose-specific [[category|Phosphotransferase system|PTS]], EIIABC
outlinks
bsu
BSU14400
BSU_14400
syns
[SW|Categories] containing this gene/protein
[SW|phosphotransferase systems], [SW|utilization of specific carbon sources], [SW|membrane proteins], [SW|phosphoproteins]
The protein
Catalyzed reaction/ biological activity
Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine (according to Swiss-Prot)
D-fructose + Nπ-phospho-L-histidyl-[protein] --> D-fructose 1-phosphate + L-histidyl-[protein] (according to UniProt)
The protein
Protein family
[SW|PTS] permease, fructose/ mannitol permease (Fru) family [Pubmed|10627040]
[[category|Phosphotransferase system|PTS]] permease, fructose/ mannitol family [Pubmed|10627040]
The protein
Paralogous protein(s)
[[protein|ManP]]
[[this]]
The protein
[SW|Interactions]
[[protein|FruA]]-[[PtsH|HPr]]
[[protein|FruA]] is a member of a suspected group of hubs proteins that were suggested to be involved in a large number of [SW|interactions] [Pubmed|21630458]
Expression and Regulation
Operon
''[[protein|fruR]]-[[protein|fruK]]-[[protein|fruA]]'' (according to [http://dbtbs.hgc.jp/COG/prom/fruRKA.html DBTBS])
Expression and Regulation
Regulation
induced in the presence of fructose ([[protein|FruR]]) (according to [http://dbtbs.hgc.jp/COG/prom/fruRKA.html DBTBS])
Expression and Regulation
Regulatory mechanism
[[protein|FruR]]: transcription repression (according to [http://dbtbs.hgc.jp/COG/prom/fruRKA.html DBTBS])
proteinLength
635
geneLength
1908
Gene
Coordinates
1,509,256 1,511,163
The protein
[SW|Domains]
[SW|PTS EIIA domain] type-2 (aa 5-149) (according to UniProt)
[SW|PTS EIIB domain] type-2 (aa 172-267) (according to UniProt)
[SW|PTS EIIC domain] type-2 (aa 301-635) (according to UniProt)
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
BKE14400 ([[gene|fruA]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE14400 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TATTTTCACTTGTGTTTCCT, downstream forward: _UP4_TAAGAAAAAAAGCGTCCTTG
BKK14400 ([[gene|fruA]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK14400 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TATTTTCACTTGTGTTTCCT, downstream forward: _UP4_TAAGAAAAAAAGCGTCCTTG