SubtiBank SubtiBank
Version comparison:

Mon Aug 31 2015 13:55:41 GMT+0200 (CEST)2025-05-31 11:03:29

description

late competence protein required for DNA binding and uptake

dCMP deaminase, late competence protein required for DNA binding and uptake, recruitment of [[protein|ComGA]] to the cell pole

locus

BSU25580

BSU_25580

function

genetic compentence

recruitment of [[protein|ComGA]] to the cell pole

product

late competence protein

dCMP deaminase

ec

outlinks

bsu

BSU25580

BSU_25580

syns

comD

[SW|Categories] containing this gene/protein

[SW|genetic competence], [SW|membrane proteins]

The protein

Protein family

cytidine and deoxycytidylate deaminase family (according to Swiss-Prot)

[SW|Cytidine and deoxycytidylate deaminase family] (according to UniProt)

The protein

[SW|Localization]

cell membrane (according to Swiss-Prot)

localizes to one or both cell poles [Pubmed|21278288]

localizes to one or both cell poles [Pubmed|31954084,21278288]

Expression and Regulation

Operon

''[SW|comEA]-[SW|comEB]-[SW|comEC]'' [Pubmed|7968523,19028902]

Expression and Regulation

[SW|Sigma factor]

[[protein|SigA]] [Pubmed|7968523]

Expression and Regulation

Regulatory mechanism

post-translational control by [[protein|ComN]] [Pubmed|19028902]

''[[protein|yutB]]'' is required for transcription [Pubmed|19028902]

[[protein|ComK]]: transcription activation [Pubmed|8196543]

References

11814663, 7968523, 21278288, 19028902

11814663, 7968523, 21278288, 19028902, 18255096, 31954084

proteinLength

189

geneLength

570

Gene

Coordinates

2,639,877 2,640,446

The protein

Catalyzed reaction/ biological activity

recruitment of [[protein|ComGA]] to the cell pole [pubmed|31954084]

deoxycytidylate monophosphate (dCMP) deaminase [pubmed|31954084]

The protein

Paralogous protein(s)

[[this]]

The protein

[SW|Domains]

[SW|CMP/dCMP-type deaminase domain] (aa 5–132) (according to UniProt)

The protein

Structure

[PDB|2HVV] (from Streptococcus mutans, 50% identity) [pubmed|18255096]

Expression and Regulation

Operons

[[this]]

Expression and Regulation

Other regulations

[[this]]

Biological materials

Mutant

BKE25580 ([[gene|comEB]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE25580 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACGTTGTTCCCTCCAAATG, downstream forward: _UP4_CTTTTCACGAGCTACGTGTG

BKK25580 ([[gene|comEB]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK25580 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACGTTGTTCCCTCCAAATG, downstream forward: _UP4_CTTTTCACGAGCTACGTGTG