Mon Aug 31 2015 13:55:41 GMT+0200 (CEST)2025-05-31 11:03:29
description
late competence protein required for DNA binding and uptake
dCMP deaminase, late competence protein required for DNA binding and uptake, recruitment of [[protein|ComGA]] to the cell pole
locus
BSU25580
BSU_25580
function
genetic compentence
recruitment of [[protein|ComGA]] to the cell pole
product
late competence protein
dCMP deaminase
ec
outlinks
bsu
BSU25580
BSU_25580
syns
comD
[SW|Categories] containing this gene/protein
[SW|genetic competence], [SW|membrane proteins]
The protein
Protein family
cytidine and deoxycytidylate deaminase family (according to Swiss-Prot)
[SW|Cytidine and deoxycytidylate deaminase family] (according to UniProt)
The protein
[SW|Localization]
cell membrane (according to Swiss-Prot)
localizes to one or both cell poles [Pubmed|21278288]
localizes to one or both cell poles [Pubmed|31954084,21278288]
Expression and Regulation
Operon
''[SW|comEA]-[SW|comEB]-[SW|comEC]'' [Pubmed|7968523,19028902]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigA]] [Pubmed|7968523]
Expression and Regulation
Regulatory mechanism
post-translational control by [[protein|ComN]] [Pubmed|19028902]
''[[protein|yutB]]'' is required for transcription [Pubmed|19028902]
[[protein|ComK]]: transcription activation [Pubmed|8196543]
References
proteinLength
189
geneLength
570
Gene
Coordinates
2,639,877 2,640,446
The protein
Catalyzed reaction/ biological activity
recruitment of [[protein|ComGA]] to the cell pole [pubmed|31954084]
deoxycytidylate monophosphate (dCMP) deaminase [pubmed|31954084]
The protein
Paralogous protein(s)
[[this]]
The protein
[SW|Domains]
[SW|CMP/dCMP-type deaminase domain] (aa 5–132) (according to UniProt)
The protein
Structure
[PDB|2HVV] (from Streptococcus mutans, 50% identity) [pubmed|18255096]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
BKE25580 ([[gene|comEB]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE25580 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACGTTGTTCCCTCCAAATG, downstream forward: _UP4_CTTTTCACGAGCTACGTGTG
BKK25580 ([[gene|comEB]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK25580 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACGTTGTTCCCTCCAAATG, downstream forward: _UP4_CTTTTCACGAGCTACGTGTG