Wed Aug 24 2016 13:22:41 GMT+0200 (CEST)2025-05-16 07:58:02
locus
BSU28430
BSU_28430
ec
outlinks
bsu
BSU28430
BSU_28430
[SW|Categories] containing this gene/protein
[SW|carbon core metabolism], [SW|membrane proteins]
Gene
Coordinates on the chromosome (coding sequence)
2,905,571 -> 2,906,332
The protein
Catalyzed reaction/ biological activity
Succinate acceptor = fumarate reduced acceptor (according to Swiss-Prot)
quinone + succinate --> quinol + fumarate (according to UniProt)
The protein
Protein family
succinate dehydrogenase/fumarate reductase iron-sulfur protein family (according to Swiss-Prot)
succinate dehydrogenase/fumarate reductase iron-sulfur protein family (single member, according to UniProt)
The protein
[SW|Cofactors]
[3 Fe- 4 S] cluster
Fe-S cluster [pubmed|29292548]
The protein
Structure
[PDB|1NEK] (''E. coli'')
[PDB|1NEK] (''E. coli'') [pubmed|12560550]
The protein
[SW|Interactions]
[[protein|SdhA]]-[[protein|SdhB]], [[protein|SdhB]]-[[protein|SdhC]] (as part of the [[protein|SdhC]]-[[protein|SdhB]]-[[protein|SdhA]] complex)
part of a [SW|respiratory supercomplex] [Pubmed|23880299]
Expression and Regulation
Operon
''[[protein|sdhC]]''-''[[protein|sdhA]]''-''[[protein|sdhB]]'' [Pubmed|3036777]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigA]] [Pubmed|2495271]
Expression and Regulation
Regulation
constitutive
part of the iron sparing response ([[protein|FsrA]]) [Pubmed|22389480]
Expression and Regulation
Regulatory mechanism
[[protein|FsrA]]: translation inhibition [Pubmed|22389480]
Biological materials
Mutant
GP792 (''[[protein|sdhC]]-[[protein|sdhA]]-[[protein|sdhB]]''::''phleo''), available in [SW|Jörg Stülke]'s lab
GP792 ∆(''[[gene|sdhC]]-[[gene|sdhA]]-[[gene|sdhB]]'')::''phleo'', available in [SW|Jörg Stülke]'s lab
GP2342 ∆(''[[gene|sdhC]]-[[gene|sdhA]]-[[gene|sdhB]]'')::''kan'', Cre-recombinase is integrated in ''[[gene|sacA]]'', available in [SW|Jörg Stülke]'s lab
GP2343 ∆(''[[gene|sdhC]]-[[gene|sdhA]]-[[gene|sdhB]]'')::''lox72'', Cre-recombinase is integrated in ''[[gene|sacA]]'', available in [SW|Jörg Stülke]'s lab
BKE28430 ∆([[gene|sdhB]])::erm trpC2 available at [http://www.bgsc.org/getdetail.php?bgscid=BKE28430 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TATGGTTTTTTGTTCACTCA, downstream forward: _UP4_TAAGAAGAAAAAACCTCTTC
BKK28430 ∆([[gene|sdhB]])::kan trpC2 available at [http://www.bgsc.org/getdetail.php?bgscid=BKK28430 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TATGGTTTTTTGTTCACTCA, downstream forward: _UP4_TAAGAAGAAAAAACCTCTTC
References
Original publications
proteinLength
253
geneLength
762
Gene
Coordinates
2,905,571 2,906,332
The protein
Paralogous protein(s)
[[this]]
The protein
[SW|Domains]
[SW|4Fe-4S ferredoxin-type domain] (aa 146-174) (according to UniProt)
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]