Wed Feb 15 2017 17:48:01 GMT+0100 (CET)2025-05-09 00:58:24
locus
BSU30190
BSU_30190
ec
outlinks
bsu
BSU30190
BSU_30190
[SW|Categories] containing this gene/protein
[SW|biosynthesis of cofactors]
Gene
Coordinates on the chromosome (coding sequence)
3,089,226 -> 3,090,413
The protein
Catalyzed reaction/ biological activity
formation of pimelic acid via a multiple-step oxidative cleavage of long-chain fatty acids
formation of pimelic acid via a multiple-step oxidative cleavage of long-chain fatty acids
C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin] --> fatty aldehyde + 3 H+ + 3 H2O + 2 oxidized [flavodoxin] + pimeloyl-[ACP] (according to UniProt)
The protein
Protein family
[SW|cytochrome P450] family (according to Swiss-Prot)
[SW|cytochrome P450] family (according to UniProt)
The protein
[SW|Interactions]
[[protein|Fer]]-[[protein|BioI]] [Pubmed|12538057]
[[protein|YkuP]]-[[protein|BioI]] [Pubmed|15449930]
[[protein|AcpA]]-[[protein|BioI]] [Pubmed|18838690]
Expression and Regulation
Operon
''[[protein|bioW]]-[[protein|bioA]]-[[protein|bioF]]-[[protein|bioD]]-[[protein|bioB]]-[[protein|bioI]]-[[protein|ytbQ]]'' [Pubmed|8763940,8892842]
Expression and Regulation
Regulation
repressed in the presence of biotin ([[protein|BirA]]) [Pubmed|8763940,8892842]
Expression and Regulation
Regulatory mechanism
[[protein|BirA]]: transcription repression [Pubmed|8763940,8892842]
Biological materials
Mutant
MGNA-A804 (bioI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/804 NBRP B. subtilis, Japan]
MGNA-A804 (bioI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/804 NBRP B. subtilis, Japan]
BKE30190 ([[gene|bioI]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE30190 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACGTGATTTTCTCCTTTCT, downstream forward: _UP4_TAAGCCTAAGAATGTGAGTG
BKK30190 ([[gene|bioI]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK30190 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACGTGATTTTCTCCTTTCT, downstream forward: _UP4_TAAGCCTAAGAATGTGAGTG
References
Reviews
[Pubmed|21437340]==
Original publications
proteinLength
395
geneLength
1188
Gene
Coordinates
3,089,226 3,090,413
The protein
Paralogous protein(s)
[[this]]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
References
Original publications