Mon Oct 31 2016 11:08:56 GMT+0100 (CET)2025-05-13 17:55:23
description
acyl-acyl carrier protein (ACP):phosphate acyltransferase, catalyzes the synthesis of the intermediate fatty acyl-phosphate (acyl-PO4), coordinates membrane synthesis with cell division
acyl-acyl carrier protein (ACP):phosphate acyltransferase, catalyzes the synthesis of the intermediate fatty acyl-phosphate (acyl-PO4)
locus
BSU15890
BSU_15890
outlinks
bsu
BSU15890
BSU_15890
[SW|Categories] containing this gene/protein
[SW|cell division], [SW|biosynthesis of lipids], [SW|essential genes]
Gene
Coordinates on the chromosome (coding sequence)
1,662,547 -> 1,663,548
Gene
Phenotypes of a mutant
essential [Pubmed|24224907,12682299]
depletion results in sporulation deficiency (via [SW|SpoIIR]) [Pubmed|22111992]
a ts mutant forms an abberant Z-ring and has a [SW|cell division] defect [Pubmed|24224907]
essential [Pubmed|24224907,12682299]
depletion results in sporulation deficiency (via [[protein|SpoIIR]]) [Pubmed|22111992]
a ts mutant forms an abberant Z-ring and has a [SW|cell division] defect [Pubmed|24224907]
depletion results in accumulation of malonyl-CoA and of long-chain-ACPs [pubmed|32671874]
The protein
Catalyzed reaction/ biological activity
catalyzes the synthesis of the intermediate fatty acyl-phosphate (acyl-PO4)
catalyzes the synthesis of the intermediate fatty acyl-phosphate (acyl-PO4)
fatty acyl-[ACP] + phosphate --> acyl phosphate + holo-[ACP] (according to UniProt)
The protein
Protein family
plsX family (according to Swiss-Prot)
plsX family (single member, according to UniProt)
The protein
Structure
[PDB|1VI1] [Pubmed|16021622]
[PDB|1VI1] [Pubmed|16021622]
[PDB|6A1K] [pubmed|31453380]
The protein
[SW|Localization]
localizes to the cell division sites, colocalizes with the Z-ring [Pubmed|24224907]
uniformly distributed on the membrane of most cells, but occasionally appears as membrane foci as well [Pubmed|26816052]
in the presence of daptomycin, PlsX delocalizes from the membrane to the cytoplasm [Pubmed|27791134]
localizes to regions of increased fluidity in the membrane (via a short amphipathic α-peptide) [pubmed|31453380,31925177]
uniformly distributed on the membrane of most cells, but occasionally appears as membrane foci as well [Pubmed|26816052]
in the presence of daptomycin, PlsX delocalizes from the membrane to the cytoplasm [Pubmed|27791134]
The protein
[SW|Interactions]
[[protein|PlsX]]-[[protein|PlsY]] [Pubmed|19282621]
[[protein|PlsX]]-[[protein|FtsA]] [Pubmed|24224907]
Expression and Regulation
Operon
''[[protein|fapR]]-[[protein|plsX]]-[[protein|fabD]]-[[protein|fabG]]-[[protein|acpA]]'' [Pubmed|12737802,19850612]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigA]] [Pubmed|16932747]
Expression and Regulation
Regulation
induced if the cells experience an accumulation of malonyl-CoA ([[protein|FapR]]) [Pubmed|12737802]
expressed at high cell density ([[protein|ComA]]) [Pubmed|16091051]
induced upon fatty acid biosynthesis inhibition [Pubmed|21383089]
Expression and Regulation
Regulatory mechanism
[[protein|ComA]]: transcription activation ([[protein|ComA]]) [Pubmed|16091051]
[[protein|FapR]]: transcription repression [Pubmed|12737802]
References
proteinLength
333
geneLength
1002
Gene
Coordinates
1,662,547 1,663,548
The protein
Paralogous protein(s)
[[this]]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]