SubtiBank SubtiBank
Version comparison:

2019-08-01 11:15:232025-05-13 17:55:23

Gene

Phenotypes of a mutant

essential [Pubmed|24224907,12682299]

depletion results in sporulation deficiency (via [[protein|SpoIIR]]) [Pubmed|22111992]

a ts mutant forms an abberant Z-ring and has a [SW|cell division] defect [Pubmed|24224907]

essential [Pubmed|24224907,12682299]

depletion results in sporulation deficiency (via [[protein|SpoIIR]]) [Pubmed|22111992]

a ts mutant forms an abberant Z-ring and has a [SW|cell division] defect [Pubmed|24224907]

depletion results in accumulation of malonyl-CoA and of long-chain-ACPs [pubmed|32671874]

The protein

Catalyzed reaction/ biological activity

catalyzes the synthesis of the intermediate fatty acyl-phosphate (acyl-PO4)

catalyzes the synthesis of the intermediate fatty acyl-phosphate (acyl-PO4)

fatty acyl-[ACP] + phosphate --> acyl phosphate + holo-[ACP] (according to UniProt)

The protein

Structure

[PDB|1VI1] [Pubmed|16021622]

[PDB|6A1K]

[PDB|1VI1] [Pubmed|16021622]

[PDB|6A1K] [pubmed|31453380]

The protein

[SW|Localization]

uniformly distributed on the membrane of most cells, but occasionally appears as membrane foci as well [Pubmed|26816052]

in the presence of daptomycin, PlsX delocalizes from the membrane to the cytoplasm [Pubmed|27791134]

localizes to regions of increased fluidity in the membrane (via a short amphipathic α-peptide) [pubmed|31453380,31925177]

uniformly distributed on the membrane of most cells, but occasionally appears as membrane foci as well [Pubmed|26816052]

in the presence of daptomycin, PlsX delocalizes from the membrane to the cytoplasm [Pubmed|27791134]

References

12737802, 19282621, 17645809, 17557823, 8759840, 16932747, 19850612, 16091051, 21383089, 22111992, 24224907, 26816052, 16021622, 27791134

12737802, 19282621, 17645809, 17557823, 8759840, 16932747, 19850612, 16091051, 21383089, 22111992, 24224907, 26816052, 16021622, 27791134, 31453380, 31925177, 31919098, 32180316, 32671874