SubtiBank SubtiBank
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Tue Dec 13 2016 11:16:34 GMT+0100 (CET)2025-01-19 20:38:38

description

part of the condensin complex, chromosomal origin condensation and segregation

part of the [SW|condensin] complex, chromosomal origin condensation and segregation

locus

BSU23220

BSU_23220

ec

outlinks

bsu

BSU23220

BSU_23220

[SW|Categories] containing this gene/protein

[SW|DNA condensation/ segregation], [SW|essential genes]

Gene

Coordinates on the chromosome (coding sequence)

2,425,831 -> 2,426,586

Gene

Phenotypes of a mutant

essential [Pubmed|12682299]

''[[protein|scpA]]'' mutants are not viable on complex medim that allow rapid growth, but they are viable under conditions of slow growth [Pubmed|24440399,24440393]

essential [Pubmed|12682299]

''[[gene|scpA]]'' mutants are not viable on complex medim that allow rapid growth, but they are viable under conditions of slow growth [Pubmed|24440399,24440393]

The protein

Protein family

scpA family (according to Swiss-Prot)

scpA family (single member, according to UniProt)

The protein

[SW|Localization]

nucleoid (Multiple) [Pubmed|16479537]

the [SW|condensin] ([[protein|Smc]])2-[[protein|ScpA]]-[[protein|ScpB]] complex forms two bipolar assemblies on the chromosome, one in each cell half, localization depends on [SW|Spo0J] [Pubmed|24440393,23475963]

nucleoid (Multiple) [Pubmed|16479537]

the [SW|condensin] ([[protein|Smc]])2-[[protein|ScpA]]-[[protein|ScpB]] complex forms two bipolar assemblies on the chromosome, one in each cell half, localization depends on [[protein|ParA]] [Pubmed|24440393,23475963]*the [SW|condensin] ([[protein|Smc]])2-[[protein|ScpA]]-[[protein|ScpB]] complex is loaded by [[protein|ParB]] to ''parS'' centromeric sites adjacent to the replication origin, travels then from the origin to the terminus at rates >50 kb per minute [Pubmed|28154080,24440393,23475963]

The protein

[SW|Interactions]

part of the [SW|condensin] complex [Pubmed|24440399,24440393]

present as stable monomer [Pubmed|22385855]

[[protein|ScpA]]-[[protein|Smc]] [Pubmed|23353789,22385855,12100548]

[[protein|ScpA]]-[[protein|ScpB]] [Pubmed|23353789,12100548]

Expression and Regulation

Operon

''[[protein|scpA]]-[[protein|scpB]]-[[protein|ypuI]]'' [Pubmed|7934830]

Expression and Regulation

Regulation

[[protein|RelA]] dependent downregulation (Class I) during stringent response [Pubmed|11948165]

References

Reviews

22934648, 22933559, 24118085, 25460803, 26706151

22934648, 22933559, 24118085, 25460803, 26706151, 29182912, 27075410

References

Original publications

12100548, 12421306, 12065423, 7934830, 16479537, 19450516, 15009890, 11948165, 23353789, 23475963, 22385855, 24440399, 24440393, 25557547, 26253537, 25951515, 26295962, 26725510, 26904953

12100548, 12421306, 12065423, 7934830, 16479537, 19450516, 15009890, 11948165, 23353789, 23475963, 22385855, 24440399, 24440393, 25557547, 26253537, 25951515, 26295962, 26725510, 26904953, 28154080, 28286005, 28689660, 30192981, 31201090, 31175837, 32250245

proteinLength

251

geneLength

756

Gene

Coordinates

2,425,831 2,426,586

The protein

Paralogous protein(s)

[[this]]

Expression and Regulation

Operons

[[this]]

Expression and Regulation

Other regulations

[[this]]