SubtiBank SubtiBank
Version comparison:

Tue May 31 2016 20:05:01 GMT+0200 (CEST)2025-05-30 01:14:30

product

cortex morphogenic protein A, adapter protein targeting SpoIVA for degradation by ClpXP upon spore envelope defects

cortex morphogenic protein A, adapter protein targeting [[protein|SpoIVA]] for degradation by [[protein|ClpXP]] upon spore envelope defects

essential

ec

[SW|Categories] containing this gene/protein

[SW|sporulation proteins]

Gene

Coordinates on the chromosome (coding sequence)

525,021 -> 528,076

Gene

Phenotypes of a mutant

quicker progressing through the [SW|sporulation ] cycle [Pubmed|22463703]

overexpression of CmpA results in heat-sensitive sporulation [Pubmed|22463703,26387458], this can be suppressed by mutations in ''[SW|clpP]'' and ''[SW|clpX]'' [Pubmed|26387458]

quicker progressing through the [SW|sporulation ] cycle [Pubmed|22463703]

overexpression of CmpA results in heat-sensitive sporulation [Pubmed|22463703,26387458], this can be suppressed by mutations in ''[[gene|clpP]]'' and ''[[gene|clpX]]'' [Pubmed|26387458]

Protein

Catalyzed reaction/ biological activity

orchestrates spore coat and cortex assembly [Pubmed|22463703]

represses cortex assembly until spore coat assembly successfully initiates [Pubmed|22463703]

Protein

[SW|Localization]

surface of the developing spore, this depends on a functional [SW|SpoIVA] [Pubmed|22463703,26387458]

Protein

[SW|Interactions]

[SW|ClpX]-[SW|CmpA] (for [SW|ClpX]-[SW|ClpP]-dependent degradation of [SW|SpoIVA]) [Pubmed|26387458]

[SW|CmpA]-[SW|SpoIVA] (for [SW|ClpX]-[SW|ClpP]-dependent degradation of [SW|SpoIVA]) [Pubmed|26387458]

Expression and Regulation

Operon

''[SW|cmpA] '' [Pubmed|22463703,20709900]

Expression and Regulation

Sigma factor

[SW|SigE] [Pubmed|22463703]

Expression and Regulation

Regulation

expressed in mother cell during [SW|sporulation ] ([[protein|SigE]], [SW|SpoIIID]) [Pubmed|22463703]

Expression and Regulation

Regulatory mechanism

[SW|SpoIIID]: transcription activation [Pubmed|22463703]

References

Reviews

27227299

27227299, 26418292, 28408070

Gene

Coordinates

525,021 → 528,076

The protein

Catalyzed reaction/ biological activity

orchestrates spore coat and cortex assembly [Pubmed|22463703]

represses cortex assembly until spore coat assembly successfully initiates [Pubmed|22463703]

The protein

[SW|Localization]

surface of the developing spore, this depends on a functional [[protein|SpoIVA]] [Pubmed|22463703,26387458]

The protein

[SW|Interactions]

[[protein|ClpX]]-[[protein|CmpA]] (for [[protein|ClpX]]-[[protein|ClpP]]-dependent degradation of [[protein|SpoIVA]]) [Pubmed|26387458]

[[protein|CmpA]]-[[protein|SpoIVA]] (for [[protein|ClpX]]-[[protein|ClpP]]-dependent degradation of [[protein|SpoIVA]]) [Pubmed|26387458]

Expression and Regulation

Operons

[[this]]

Expression and Regulation

Other regulations

[[this]]