Mon Jul 04 2016 16:11:48 GMT+0200 (CEST)2025-05-22 12:24:15
description
DNA polymerase III (beta subunit), beta clamp, part of the replisome, also involved in DNA mismatch repair, inhibitor of DnaA oligomerization
DNA polymerase III (beta subunit), beta clamp, part of the [SW|replisome], also involved in DNA mismatch repair, inhibitor of [[protein|DnaA]] oligomerization
locus
BSU00020
BSU_00020
function
DNA replication, DNA repair
[[category|DNA replication]], DNA repair
product
DNA polymerase III
(beta subunit), beta clamp
DNA polymerase III (beta subunit), beta clamp
outlinks
bsu
BSU00020
BSU_00020
[SW|Categories] containing this gene/protein
[SW|DNA replication], [SW|essential genes]
Gene
Coordinates on the chromosome (coding sequence)
1,939 -> 3,075
The protein
Catalyzed reaction/ biological activity
[[protein|DnaN]] overexpression or release from the [SW|replisome] decreases association of [[protein|YabA]] with ''oriC'', increases association of [[protein|DnaA]] with ''oriC'' [Pubmed|21895792]
Deoxynucleoside triphosphate DNA(n) = diphosphate DNA(n 1) (according to Swiss-Prot)
recruits [[protein|MutS]] to the site of [SW|DNA replication] ([SW|replisome]) [Pubmed|23228104]
required for bacteriophage SPP1 replication [Pubmed|23268446]
inhibits oligomerization and helix formation of [[protein|DnaA]] [Pubmed|23909787]
[[protein|DnaN]] overexpression or release from the [SW|replisome] decreases association of [[protein|YabA]] with ''oriC'', increases association of [[protein|DnaA]] with ''oriC'' [Pubmed|21895792]
recruits [[protein|MutS]] to the site of [SW|DNA replication] ([SW|replisome]) [Pubmed|23228104]
required for bacteriophage SPP1 replication [Pubmed|23268446]
inhibits oligomerization and helix formation of [[protein|DnaA]] [Pubmed|23909787]
The protein
Structure
[PDB|2AWA] (from ''Streptococcus pneumoniae'', 41% identity, 77% similarity)
[PDB|4TR6] [pubmed|25170813]
[PDB|6E8D] (complex with [[protein|MutL]]) [Pubmed|30916336]
The protein
[SW|Localization]
nucleoid (mid-cell spot) [Pubmed|9822387] [Pubmed|16479537]
forms large assemblies on DNA, called
forms foci [Pubmed|21958350]
nucleoid (mid-cell spot) [Pubmed|9822387] [Pubmed|16479537]
forms large assemblies on DNA, called
forms foci [Pubmed|21958350]
The protein
[SW|Interactions]
[[protein|DnaA]]-[[protein|YabA]]-[[protein|DnaN]] [Pubmed|12060778]
part of the [SW|replisome]: [[protein|PolC]]-[[protein|HolA]]-[[protein|HolB]]-[[protein|DnaX]]-[[protein|DnaN]]-[[protein|DnaG]]-[[protein|DnaC]]-[[protein|DnaI]]-[[protein|DnaD]]-[[protein|SsbA]]-[[protein|DnaE]]-[[protein|PriA]]-[[protein|DnaB]] [Pubmed|20122408]
[SW|PolY1]-[[protein|DnaN]], [SW|PolY2]-[[protein|DnaN]] (required for untargeted mutagenesis) [Pubmed|15469515]
[SW|PolY1]-[[protein|PolA]]-[[protein|DnaN]] [Pubmed|16045613]
[[protein|MutL]] (C-terminal domain)-[[protein|DnaN]], the interaction stimulates the endonuclease activity of [SW|MutL] [Pubmed|26384423,21050827]
[[protein|MutS]]-[[protein|DnaN]] [Pubmed|20453097]
[[protein|DnaE]]-[[protein|DnaN]] [Pubmed|21958350]
[[protein|DnaN]] forms dimers [Pubmed|16045613]
Expression and Regulation
Operon
''[[protein|dnaA]]-[[protein|dnaN]]'' [Pubmed|2987848]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigA]] [Pubmed|2987848]
Expression and Regulation
Regulation
negatively controlled by [[protein|DnaA]] [Pubmed|2168872] and [SW|Spo0A] [Pubmed|14651647]
repressed under conditions that trigger sporulation ([SW|Spo0A]) [Pubmed|14651647]
Expression and Regulation
Regulatory mechanism
[SW|Spo0A]: transcription repression [Pubmed|14651647]
References
Reviews
References
Original publications
proteinLength
378
geneLength
1137
Gene
Coordinates
1,939 3,075
The protein
Protein family
Beta sliding clamp family (single member, according to UniProt)
The protein
Paralogous protein(s)
[[this]]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]