Mon Aug 31 2015 13:53:36 GMT+0200 (CEST)2025-05-24 03:21:07
locus
BSU11220
BSU_11220
outlinks
bsu
BSU11220
BSU_11220
syns
[SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids]
The protein
Catalyzed reaction/ biological activity
N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate (according to Swiss-Prot)
2-oxoglutarate + N2-acetyl-L-ornithine --> L-glutamate + N-acetyl-L-glutamate 5-semialdehyde (according to UniProt)
The protein
Protein family
ArgD subfamily (according to Swiss-Prot)
[SW|Class-III pyridoxal-phosphate-dependent aminotransferase family] (according to UniProt)
Expression and Regulation
Operon
''[[protein|argC]]-[[protein|argJ]]-[[protein|argB]]-[[protein|argD]]-[[protein|carA]]-[[protein|carB]]-[[protein|argF]]'' [Pubmed|7511775]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigA]] [Pubmed|7511775]
Expression and Regulation
Regulation
repressed by casamino acids ([[protein|CodY]]) [Pubmed|12107147]
repressed by arginine ([[protein|AhrC]]) [Pubmed|1312212]
Expression and Regulation
Regulatory mechanism
[[protein|AhrC]]: transcription repression [Pubmed|1312212]
[[protein|CodY]]: transcription repression [Pubmed|24843172]
References
proteinLength
385
geneLength
1155
Gene
Coordinates
1,198,099 → 1,199,256
The protein
Paralogous protein(s)
[[this]]
The protein
[SW|Cofactors]
PLP (according to UniProt)
The protein
Structure
[PDB|2EH6] (from Aquifex aeolicus, 45% identity)
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
BKE11220 (Δ[[gene|argD]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE11220 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GCTCATGAAACAGCCTCCTT, downstream forward: _UP4_TGATTTTTTTTCGATATAAA
BKK11220 (Δ[[gene|argD]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK11220 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GCTCATGAAACAGCCTCCTT, downstream forward: _UP4_TGATTTTTTTTCGATATAAA