Wed Feb 15 2017 18:07:28 GMT+0100 (CET)2025-05-29 12:01:45
description
GTP cyclohydrolase I
GTP cyclohydrolase I, required for the initial step of queuosine synthesis ([SW|tRNA modification])
locus
BSU22780
BSU_22780
function
biosynthesis of folate
biosynthesis of folate and queuosine
names
folE
mtrA
folE
outlinks
bsu
BSU22780
BSU_22780
[SW|Categories] containing this gene/protein
[SW|biosynthesis of cofactors]
Gene
Coordinates on the chromosome (coding sequence)
2,384,783 -> 2,385,355
The protein
Catalyzed reaction/ biological activity
GTP
GTP + H2O --> 7,8-dihydroneopterin 3'-triphosphate + formate + H+ (according to UniProt)
The protein
Protein family
citrate synthase family (according to Swiss-Prot)
GTP cyclohydrolase I family (with [[protein|QueF]], according to UniProt)
Expression and Regulation
Operon
''[[protein|folE]]-[[protein|mtrB]]'' [Pubmed|2123343]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigA]] [Pubmed|2123343]
Expression and Regulation
Regulation
constitutive [Pubmed|19767425]
References
proteinLength
190
geneLength
573
Gene
Coordinates
2,384,783 2,385,355
The protein
Paralogous protein(s)
[[this]]
The protein
Effectors of protein activity
the interaction with ZagA/ZTP facilitates the supply of zinc to FolE under conditions of zinc limitation, and thus enzymatic activity [pubmed|31132310]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
References
Reviews
References
Original publications