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Wed Feb 15 2017 18:07:28 GMT+0100 (CET)2025-05-29 12:01:45

description

GTP cyclohydrolase I

GTP cyclohydrolase I, required for the initial step of queuosine synthesis ([SW|tRNA modification])

locus

BSU22780

BSU_22780

function

biosynthesis of folate

biosynthesis of folate and queuosine

names

folE

mtrA

folE

outlinks

bsu

BSU22780

BSU_22780

[SW|Categories] containing this gene/protein

[SW|biosynthesis of cofactors]

Gene

Coordinates on the chromosome (coding sequence)

2,384,783 -> 2,385,355

The protein

Catalyzed reaction/ biological activity

GTP H2O = formate 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate (according to Swiss-Prot)

GTP + H2O --> 7,8-dihydroneopterin 3'-triphosphate + formate + H+ (according to UniProt)

The protein

Protein family

citrate synthase family (according to Swiss-Prot)

GTP cyclohydrolase I family (with [[protein|QueF]], according to UniProt)

Expression and Regulation

Operon

''[[protein|folE]]-[[protein|mtrB]]'' [Pubmed|2123343]

Expression and Regulation

[SW|Sigma factor]

[[protein|SigA]] [Pubmed|2123343]

Expression and Regulation

Regulation

constitutive [Pubmed|19767425]

References

1551827, 2123343, 17032654, 19767425, 28189581

proteinLength

190

geneLength

573

Gene

Coordinates

2,384,783 2,385,355

The protein

Paralogous protein(s)

[[this]]

The protein

Effectors of protein activity

the interaction with ZagA/ZTP facilitates the supply of zinc to FolE under conditions of zinc limitation, and thus enzymatic activity [pubmed|31132310]

Expression and Regulation

Operons

[[this]]

Expression and Regulation

Other regulations

[[this]]

References

Reviews

31220391

References

Original publications

1551827, 2123343, 17032654, 19767425, 28189581, 31132310