2017-12-29 17:31:192025-05-14 10:56:37
description
GTP cyclohydrolase I
GTP cyclohydrolase I, required for the initial step of queuosine synthesis ([SW|tRNA modification])
locus
BSU22780
BSU_22780
geneLength
570
573
function
biosynthesis of folate
biosynthesis of folate and queuosine
names
folE
mtrA
folE
outlinks
bsu
BSU22780
BSU_22780
Gene
Coordinates
2,384,783 → 2,385,355
2,384,783 2,385,355
The protein
Catalyzed reaction/ biological activity
GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate (according to Swiss-Prot)
GTP + H2O --> 7,8-dihydroneopterin 3'-triphosphate + formate + H+ (according to UniProt)
The protein
Protein family
citrate synthase family (according to Swiss-Prot)
GTP cyclohydrolase I family (with [[protein|QueF]], according to UniProt)
References
The protein
Paralogous protein(s)
[[this]]
The protein
Effectors of protein activity
the interaction with ZagA/ZTP facilitates the supply of zinc to FolE under conditions of zinc limitation, and thus enzymatic activity [pubmed|31132310]
References
Reviews
References
Original publications