SubtiBank SubtiBank
Version comparison:

2017-12-29 17:31:192025-05-14 10:56:37

description

GTP cyclohydrolase I

GTP cyclohydrolase I, required for the initial step of queuosine synthesis ([SW|tRNA modification])

locus

BSU22780

BSU_22780

geneLength

570

573

function

biosynthesis of folate

biosynthesis of folate and queuosine

names

folE

mtrA

folE

outlinks

bsu

BSU22780

BSU_22780

Gene

Coordinates

2,384,783 → 2,385,355

2,384,783 2,385,355

The protein

Catalyzed reaction/ biological activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate (according to Swiss-Prot)

GTP + H2O --> 7,8-dihydroneopterin 3'-triphosphate + formate + H+ (according to UniProt)

The protein

Protein family

citrate synthase family (according to Swiss-Prot)

GTP cyclohydrolase I family (with [[protein|QueF]], according to UniProt)

References

1551827, 2123343, 17032654, 19767425, 28189581

The protein

Paralogous protein(s)

[[this]]

The protein

Effectors of protein activity

the interaction with ZagA/ZTP facilitates the supply of zinc to FolE under conditions of zinc limitation, and thus enzymatic activity [pubmed|31132310]

References

Reviews

31220391

References

Original publications

1551827, 2123343, 17032654, 19767425, 28189581, 31132310