2017-8-11 16:0:3Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)
proteinLength
283
geneLength
849
essential
no
yes
Gene
Coordinates
2,528,404 → 2,529,255
Gene
Phenotypes of a mutant
essential [Pubmed|12682299], non-essential according to [Pubmed|28189581]
inactivation of ''[[gene|folD]]'' suppresses the synthetic lethality of the ''[[gene|defA]] [[gene|defB]]'' double mutant [Pubmed|27983482]
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH (according to Swiss-Prot)
5,10-methylenetetrahydrofolate
The protein
Structure
[PDB|1B0A] (from ''E. coli'', 52% identity) [Pubmed|10386884]
[PDB|1B0A] (from ''E. coli'', 52% identity)
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
References
[SW|Categories] containing this gene/protein
[SW|translation], [SW|essential genes]
Gene
Coordinates on the chromosome (coding sequence)
2,528,404 -> 2,529,255
Expression and Regulation
Operon
''[[protein|nusB]]-[[protein|folD]]'' [Pubmed|2536750,11591660]
Expression and Regulation
Regulation
repressed in the presence of purine nucleotides ([[protein|PurR]]) [Pubmed|2536750,11591660]
Expression and Regulation
Regulatory mechanism
[[protein|PurR]]: transcription repression (molecular inducer: PRPP) [Pubmed|2536750,11591660]