alpha-phosphoglucomutase, required for UDP-glucose synthesis, inhibits FtsZ ring assembly (indirect effect due to a defect in UDP-glucose synthesis)

alpha-phosphoglucomutase, required for UDP-glucose synthesis, inhibits [[protein|FtsZ]] ring assembly (indirect effect due to a defect in UDP-glucose synthesis), possesses a secondary phosphoglucosamine mutase activity

BSU09310

BSU_09310

BSU09310

BSU_09310

[SW|cell wall synthesis], [SW|lipid metabolism/ other], [SW|phosphoproteins], [SW|sporulation/ other]

1,006,774 -> 1,008,519

cells are bent and distended due to the lack of glucolipids [Pubmed|27684739]

the inactivation of ''[[protein|pgcA]]'' suppresses the poor and filamentous growth of the ''[[protein|yvcL]] [[protein|zapA]]'' double mutant [Pubmed|24097947]

inactivation of ''[SW|pgcA]'' reduces sporulation efficiency to 0.1% that of wild type cells; smaller and wider mother cells with small forespores [Pubmed|26735940]

cells are bent and distended due to the lack of glucolipids [Pubmed|27684739]

the inactivation of ''[[gene|pgcA]]'' suppresses the poor and filamentous growth of the ''[[gene|whiA]] [[gene|zapA]]'' double mutant [Pubmed|24097947]

inactivation of ''[[gene|pgcA]]'' reduces sporulation efficiency to 0.1% that of wild type cells; smaller and wider mother cells with small forespores [Pubmed|26735940]

resistant to phage SPO1 [pubmed|30811056]

a [[gene|pgcA]] [[gene|glmR]] double mutant is not viable, this can be suppressed by overexpression of [[protein|GlmM]] [pubmed|31589605]

Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate (according to Swiss-Prot)

α-D-glucose 1-phosphate --> α-D-glucose 6-phosphate (according to UniProt)

D-glucosamine 6-phosphate --> α-D-glucosamine 1-phosphate (secondary activity, this activity is increased by a G47S mutation) [pubmed|31589605]

phosphohexose mutase family (according to Swiss-Prot)

phosphohexose mutase family (with [[protein|GlmM]], [pubmed|15238632])

PgcA inhibits [[protein|FtsZ]] ring assembly (indirect effect due to a defect in UDP-glucose synthesis)[Pubmed|17662947]

PgcA inhibits [[protein|FtsZ]] ring assembly (indirect effect due to a defect in UDP-glucose synthesis)[Pubmed|17662947]

a PgcA (G47S) variant suppresses the growth defect of a [[gene|glmR]] mutant on gluconeogenic carbon sources in the absence of glucose due to the increased phosphoglucosamine mutase activity [pubmed|31589605]

MGNA-B476 (yhxB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1475 NBRP B. subtilis, Japan]

GP1743: ''pgcA::aphA3'', available in [SW|Jörg Stülke]' lab

MGNA-B476 (yhxB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1475 NBRP B. subtilis, Japan]

GP1743: BSB1 ''pgcA::aphA3'', available in [SW|Jörg Stülke]'s lab

BKE09310 ([[gene|pgcA]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE09310 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTCGTCCTCCTATGTA, downstream forward: _UP4_TAATTCAAGTATGAGCTGGG

BKK09310 ([[gene|pgcA]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK09310 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTCGTCCTCCTATGTA, downstream forward: _UP4_TAATTCAAGTATGAGCTGGG

15175311, 17726680, 16493705, 15640167, 17662947, 22396664, 24097947, 26735940, 27684739

15175311, 17726680, 16493705, 15640167, 17662947, 22396664, 24097947, 26735940, 27684739, 15238632, 30811056, 31589605

581

1746

1,006,774 1,008,519

[[this]]

[PDB|2Z0F] (from Thermus thermophilus, 27% identity)

[[this]]

[[this]]