Tue Dec 13 2016 11:16:30 GMT+0100 (CET)2025-05-22 03:52:54
description
high-affinity ABC transporter for zinc (ATP-binding protein)
high-affinity [SW|ABC transporter] for zinc (ATP-binding protein)
locus
BSU02860
BSU_02860
product
ABC transporter for zinc (ATP-binding protein)
[SW|ABC transporter] for zinc (ATP-binding protein)
names
znuC
ycdI
znuC
ycdI
adcC
outlinks
bsu
BSU02860
BSU_02860
aminos
MNLVSLKDIVFGYSHTPVLDKVSLDIESGEFVGITGPNGASKSTLIKVMLGMLKPWEGTVTISKRNTEGKRLTIGYVPQQISSFNAGFPSTVLELVQSGRYTKGKWFKRLNEEDHLEVEKALKMVEMWDLRHRKIGDLSGGQKQKICIARMLASNPDLLMLDEPTTAVDYDSRKGFYEFMHHLVKNHNRTVVMVTHEQNEVQQFLDKVIRLERGEKGGWKCLTWNSCDELF
[SW|Categories] containing this gene/protein
[SW|ABC transporters], [SW|trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)], [SW|membrane proteins]
Gene
Coordinates on the chromosome (coding sequence)
309,347 -> 310,042
Gene
Phenotypes of a mutant
reduced genetic competence, can be rescued by the addition of excess zinc [Pubmed|21813502]
reduced expression of the ''[SW|comFA]-[SW|comFB]-[SW|comFC]-[[protein|yvyF]]-[[protein|flgM]]-[[protein|yvyG]]-[[protein|flgK]]-[[protein|flgL]]'' operon [Pubmed|21813502]
reduced genetic competence, can be rescued by the addition of excess zinc [Pubmed|21813502]
reduced expression of the ''[[gene|comFA]]-[[gene|comFB]]-[[gene|comFC]]-[[gene|yvyF]]-[[gene|flgM]]-[[gene|yvyG]]-[[gene|flgK]]-[[gene|flgL]]'' operon [Pubmed|21813502]
The protein
Protein family
[SW|ABC transporter] domain (according to Swiss-Prot)
[SW|ABC transporter superfamily] (according to UniProt)
Expression and Regulation
Operon
''[[protein|znuA]]-[[protein|znuC]]-[[protein|znuB]]'' [Pubmed|9811636]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigA]] [Pubmed|12426338]
Expression and Regulation
Regulation
induced by zinc starvation ([[protein|Zur]]) [Pubmed|12426338]
Expression and Regulation
Regulatory mechanism
[[protein|Zur]]: transcription repression in the presence of zinc [Pubmed|12426338]
part of the second wave of induction upon zinc depletion [Pubmed|27561249]
proteinLength
231
geneLength
696
Gene
Coordinates
309,347 310,042
The protein
Paralogous protein(s)
[[this]]
The protein
[SW|Domains]
[SW|ABC transporter domain] (aa 4-230) (according to UniProt)
The protein
[SW|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
MGNA-B981 (ycdI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1980 NBRP B. subtilis, Japan]
BKE02860 ([[gene|znuC]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE02860 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTAATCTTCCTTTCTC, downstream forward: _UP4_GGATGGAAATGTTTGACTTG
BKK02860 ([[gene|znuC]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK02860 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTAATCTTCCTTTCTC, downstream forward: _UP4_GGATGGAAATGTTTGACTTG