Tue Dec 13 2016 11:16:31 GMT+0100 (CET)2025-05-24 06:02:41
description
multidrug ABC transporter (ATP-binding protein), also involved in the signalling pathway to activate KinA at the onset of sporulation
multidrug [SW|ABC transporter ](ATP-binding protein), also involved in the signalling pathway to activate [[protein|KinA ]]at the onset of [SW|sporulation]
locus
BSU09710
BSU_09710
product
multidrug ABC transporter (ATP-binding protein)
multidrug [SW|ABC transporter ](ATP-binding protein)
ec
outlinks
bsu
BSU09710
BSU_09710
aminos
MFSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAIDDMKAGAFTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHLLTMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFLTMGFLISWKLTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRVLESVSGVRVIRAYVQETNDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKLLVGASYLIGLGYGAFLVFRNELTLGELVSFNVYLGMMIWPMFAIGELINVMQRGNASLDRVNETLSYETDVTDPKQPADLKEPGDIVFSHVSFTYPSSTSDNLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGEGSITFSGVPIQQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAEAHFEKDLHMLPSGLETMVGEKGVALSGGQKQRISIARALMANPEILILDDSLSAVDAKTEAAIIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIAERGTHQELLANNGWYREQYERQQLFTAEEGGAGA
[SW|Categories] containing this gene/protein
[SW|ABC transporters], [SW|resistance against toxins/ antibiotics], [SW|membrane proteins], [SW|sporulation proteins]
Gene
Coordinates on the chromosome (coding sequence)
1,045,318 -> 1,047,075
The protein
[SW|Domains]
has both a membrane-spanning and an ATP-binding domain [Pubmed|10092453]
has both a membrane-spanning and an ATP-binding domain [Pubmed|10092453]
[SW|ABC transmembrane type-1 domain] (aa 19-304) (according to UniProt)
[SW|ABC transporter domain] (aa 337-572) (according to UniProt)
The protein
[SW|Interactions]
[[protein|BmrC]]-[[protein|BmrD]] [Pubmed|19167342]
Expression and Regulation
Operon
''[[protein|bmrB]]-[[protein|bmrC]]-[[protein|bmrD]]'' [Pubmed|25217586]
Expression and Regulation
Regulation
induced in response to antibiotics that target protein synthesis ([[protein|BmrB]]) [Pubmed|25217586]
''[[protein|bmrC]]-[[protein|bmrD]]'' expression only occurs during the late-exponential and stationary growth stages, irrespective of the timing of the antibiotic challenge ([[protein|AbrB]]) [Pubmed|25217586]
Expression and Regulation
Regulatory mechanism
[[protein|AbrB]]: transcription repression [Pubmed|25217586]
[[protein|BmrB]]: transcriptional attenuation [Pubmed|25217586]
References
proteinLength
585
geneLength
1758
Gene
Coordinates
1,045,318 1,047,075
The protein
Protein family
[SW|ABC transporter superfamily] (according to UniProt)
The protein
Paralogous protein(s)
[[this]]
The protein
Structure
[PDB|5MKK] (TmrAB complex from Thermus thermophilus, 35% identity) [pubmed|28069938]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
MGNA-B490 (yheI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1489 NBRP B. subtilis, Japan]
BKE09710 ([[gene|bmrC]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE09710 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTATCCCCATCTCCTCA, downstream forward: _UP4_GCGGAAGAAGGGGGAGCAGG
BKK09710 ([[gene|bmrC]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK09710 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTATCCCCATCTCCTCA, downstream forward: _UP4_GCGGAAGAAGGGGGAGCAGG