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Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)2025-05-13 13:35:20

description

ATPase, centromere-like function involved in forespore chromosome partitioning / negative regulation of sporulation initiation

ATPase, centromere-like function involved in forespore chromosome partitioning / negative regulation of [[category|Sporulation]] initiation

locus

BSU40970

BSU_40970

function

forespore chromosome partitioning /
negative regulation of sporulation initiation

forespore chromosome partitioning / negative regulation of [[category|Sporulation]] initiation

product

negative regulator of sporulation initiation

negative regulator of [[category|Sporulation]] initiation

ec

outlinks

bsu

BSU40970

BSU_40970

[SW|Categories] containing this gene/protein

[SW|DNA condensation/ segregation], [SW|sporulation/ other], [SW|membrane proteins]

Gene

Coordinates on the chromosome (coding sequence)

4,206,397 -> 4,207,158

The protein

Catalyzed reaction/ biological activity

regulates [SW|DNA replication] initiation by either inhibiting or activating the [SW|DNA replication] initiator protein [[protein|DnaA]] [Pubmed|21235642]; regulation of ''Spo0A'' expression [Pubmed|10852876]

regulates [SW|DNA replication] initiation by either inhibiting or activating the [SW|DNA replication] initiator protein [[protein|DnaA]] [Pubmed|21235642]; regulation of ''Spo0A'' expression [Pubmed|10852876]

ATP + H2O --> ADP + H+ + phosphate (according to UniProt)

The protein

Protein family

parA family (according to Swiss-Prot)

ParA family (with [[protein|FlhG]] and [[protein|MinD]], according to UniProt)

The protein

[SW|Interactions]

[[protein|ParA]]-[[protein|ParB]] [Pubmed|21235642]

[[protein|ParA]]-[[protein|DnaA]] [Pubmed|22286949]

Expression and Regulation

Operon

''[[protein|parA]]-[[protein|parB]]'' [Pubmed|22383849]

Expression and Regulation

Regulation

repressed under conditions that trigger sporulation ([SW|Spo0A]) [Pubmed|14651647]

Expression and Regulation

Regulatory mechanism

[SW|Spo0A]: transcription repression [Pubmed|14651647]

Labs working on this gene/protein

[SW|Heath Murray], Centre for Bacterial Cell Biology, Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/heath.murray homepage]

References

Reviews

20157337, 22934648, 26286503, 26706151

20157337, 22934648, 26286503, 26706151, 28075389, 30863373

References

Original publications

15659156, 11532141, 19450516, 18854156, 10619015, 8866474, 12492861, 9701805, 12950914, 14651647, 19450516, 20566861, 21235642, 10852876, 14563866, 26253537, 22286949, 21911367, 27059541

15659156, 11532141, 19450516, 18854156, 10619015, 8866474, 12492861, 9701805, 12950914, 14651647, 19450516, 20566861, 21235642, 10852876, 14563866, 26253537, 22286949, 21911367, 27059541, 27489185, 28373206, 27489185, 31318889

proteinLength

253

geneLength

762

Gene

Coordinates

4,206,397 4,207,158

Gene

Phenotypes of a mutant

defective in oriC segregation during [[category|Sporulation]] [pubmed|27489185]

The protein

Paralogous protein(s)

[[this]]

The protein

Structure

[PDB|5U1G] [pubmed|28373206]

[PDB|5U1J] [pubmed|28373206]

Expression and Regulation

Operons

[[this]]

Expression and Regulation

Other regulations

[[this]]

Biological materials

Mutant

BKE40970 ([[gene|parA]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE40970 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACGATGTCACCTACTTTCA, downstream forward: _UP4_GATTTAGCAAAGGAAGTGGC

BKK40970 ([[gene|parA]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK40970 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACGATGTCACCTACTTTCA, downstream forward: _UP4_GATTTAGCAAAGGAAGTGGC

labs

[SW|Heath Murray], Centre for Bacterial Cell Biology, Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/heath.murray homepage]