Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)2025-05-13 13:35:20
description
ATPase, centromere-like function involved in forespore chromosome partitioning / negative regulation of sporulation initiation
ATPase, centromere-like function involved in forespore chromosome partitioning / negative regulation of [[category|Sporulation]] initiation
locus
BSU40970
BSU_40970
function
forespore chromosome partitioning /
negative regulation of sporulation initiation
forespore chromosome partitioning / negative regulation of [[category|Sporulation]] initiation
product
negative regulator of sporulation initiation
negative regulator of [[category|Sporulation]] initiation
ec
outlinks
bsu
BSU40970
BSU_40970
[SW|Categories] containing this gene/protein
[SW|DNA condensation/ segregation], [SW|sporulation/ other], [SW|membrane proteins]
Gene
Coordinates on the chromosome (coding sequence)
4,206,397 -> 4,207,158
The protein
Catalyzed reaction/ biological activity
regulates [SW|DNA replication] initiation by either inhibiting or activating the [SW|DNA replication] initiator protein [[protein|DnaA]] [Pubmed|21235642]; regulation of ''Spo0A'' expression [Pubmed|10852876]
regulates [SW|DNA replication] initiation by either inhibiting or activating the [SW|DNA replication] initiator protein [[protein|DnaA]] [Pubmed|21235642]; regulation of ''Spo0A'' expression [Pubmed|10852876]
ATP + H2O --> ADP + H+ + phosphate (according to UniProt)
The protein
Protein family
parA family (according to Swiss-Prot)
ParA family (with [[protein|FlhG]] and [[protein|MinD]], according to UniProt)
The protein
[SW|Interactions]
[[protein|ParA]]-[[protein|ParB]] [Pubmed|21235642]
[[protein|ParA]]-[[protein|DnaA]] [Pubmed|22286949]
Expression and Regulation
Operon
''[[protein|parA]]-[[protein|parB]]'' [Pubmed|22383849]
Expression and Regulation
Regulation
repressed under conditions that trigger sporulation ([SW|Spo0A]) [Pubmed|14651647]
Expression and Regulation
Regulatory mechanism
[SW|Spo0A]: transcription repression [Pubmed|14651647]
Labs working on this gene/protein
[SW|Heath Murray], Centre for Bacterial Cell Biology, Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/heath.murray homepage]
References
Reviews
References
Original publications
proteinLength
253
geneLength
762
Gene
Coordinates
4,206,397 4,207,158
Gene
Phenotypes of a mutant
defective in oriC segregation during [[category|Sporulation]] [pubmed|27489185]
The protein
Paralogous protein(s)
[[this]]
The protein
Structure
[PDB|5U1G] [pubmed|28373206]
[PDB|5U1J] [pubmed|28373206]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
BKE40970 ([[gene|parA]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE40970 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACGATGTCACCTACTTTCA, downstream forward: _UP4_GATTTAGCAAAGGAAGTGGC
BKK40970 ([[gene|parA]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK40970 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACGATGTCACCTACTTTCA, downstream forward: _UP4_GATTTAGCAAAGGAAGTGGC
labs
[SW|Heath Murray], Centre for Bacterial Cell Biology, Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/heath.murray homepage]