2017-05-09 15:36:342025-04-05 02:54:30
description
DNA-binding protein, spatial regulator of cell division to protect the nucleoid, and timing device with an important role in the coordination of chromosome segregation and cell division, Z ring placement
DNA-binding protein, spatial regulator of [SW|cell division] to protect the nucleoid, and timing device with an important role in the coordination of chromosome segregation and [SW|cell division], Z ring placement, coordination of early steps in DNA replication with establishment of a medial division site
locus
BSU40990
BSU_40990
geneLength
849
852
function
control of cell division
control of [SW|cell division]
ec
outlinks
bsu
BSU40990
BSU_40990
Gene
Coordinates
4,207,897 → 4,208,748
4,207,897 4,208,748
The protein
Catalyzed reaction/ biological activity
binds specific sites on the chromosome [Pubmed|19494834]
binds specific sites on the chromosome [Pubmed|19494834]
prevents Z ring assembly over the bacterial nucleoid and helps fine tune the assembly of the Z ring at midcell during the cell cycle [pubmed|31152469]
The protein
Protein family
ParB family (according to Swiss-Prot)
ParB family (with [[protein|ParB]], according to UniProt)
The protein
Paralogous protein(s)
[[protein|ParA]]
[[this]]
Biological materials
Mutant
MGNA-B874 (yyaA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1873 NBRP B. subtilis, Japan]
MGNA-B874 (yyaA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1873 NBRP B. subtilis, Japan]
BKE40990 ([[gene|noc]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE40990 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTACCTACACCACCTTT, downstream forward: _UP4_TAGAAGCTCTCCTGAAAAGC
BKK40990 ([[gene|noc]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK40990 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTACCTACACCACCTTT, downstream forward: _UP4_TAGAAGCTCTCCTGAAAAGC
Labs working on this gene/protein
Jeff Errington, Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/jeff.errington Homepage]
References
Reviews
References
Original Publications
The protein
Structure
[PDB|1VZ0] ([[protein|ParB]] from Thermus thermophilus, 48% from aa 30 ... 219) [pubmed|15228524]
labs
Jeff Errington, Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/jeff.errington Homepage]
David Rudner, Harvard, USA [http://rudnerlab.med.harvard.edu/ Homepage]