Tue Dec 13 2016 11:16:30 GMT+0100 (CET)2025-05-29 09:03:33
locus
BSU03790
BSU_03790
outlinks
bsu
BSU03790
BSU_03790
aminos
MKVVKFGGSSLASGAQLDKVFHIVTSDPARKAVVVSAPGKHYAEDTKVTDLLIACAEQYLATGSAPELAEAVVERYALIANELQLGQSIIEKIRDDLFTLLEGDKSNPEQYLDAVKASGEDNNAKLIAAYFRYKGVKAEYVNPKDAGLFVTNEPGNAQVLPESYQNLYRLRERDGLIIFPGFFGFSKDGDVITFSRSGSDITGSILANGLQADLYENFTDVDAVYSVNPSFVENPKEISELTYREMRELSYAGFSVFHDEALIPAFRAGIPVQIKNTNNPSAEGTRVVSKRDNTNGPVVGIASDTGFCSIYISKYLMNREIGFGRRALQILEEHGLTYEHVPSGIDDMTIILRQGQMDAATERSVIKRIEEDLHADEVIVEHHLALIMVVGEAMRHNVGTTARAAKALSEAQVNIEMINQGSSEVSMMFGVKEAEERKAVQALYQEFFAGVLIS
[SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids]
Gene
Coordinates on the chromosome (coding sequence)
430,623 -> 431,987
The protein
Catalyzed reaction/ biological activity
ATP
ATP + L-aspartate --> 4-phospho-L-aspartate + ADP (according to UniProt)
The protein
Protein family
aspartokinase family (according to Swiss-Prot)
aspartokinase family (with [[protein|DapG]] and [[protein|LysC]], according to UniProt)
Expression and Regulation
Operon
''thrD'' [Pubmed|22383849]
Expression and Regulation
Regulation
expressed in the presence of lysine or cysteine ([SW|ThrR]) [Pubmed|27260660]
Expression and Regulation
Regulatory mechanism
[[protein|CodY]]: transcription repression [Pubmed|23569278]
[[protein|ThrR]]: transcription repression [Pubmed|27260660]
Biological materials
lacZ fusion
pBP318 (in [[protein|pAC5]]), available in [SW|Fabian Commichau]'s lab [Pubmed|27260660]
pBP318 (in [SW|pAC5]), available in [SW|Fabian Commichau]'s lab [Pubmed|27260660]
References
Original publications
proteinLength
454
geneLength
1365
Gene
Coordinates
430,623 431,987
The protein
Paralogous protein(s)
[[this]]
The protein
[SW|Domains]
2 [SW|ACT domain]s (aa 312-388, aa 389-454) (according to UniProt)
The protein
Structure
[PDB|3TVI] (from Clostridium acetobutylicum, 37% identity) [pubmed|25170437]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
MGNA-C009 (yclM::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2007 NBRP B. subtilis, Japan]
BKE03790 (Δ[[gene|thrD]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE03790 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTTACATCTCCTAATG, downstream forward: _UP4_TAATCGTACATAAATAGCGG
BKK03790 (Δ[[gene|thrD]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK03790 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTTACATCTCCTAATG, downstream forward: _UP4_TAATCGTACATAAATAGCGG