Tue Oct 13 2015 12:40:43 GMT+0200 (CEST)2025-04-07 04:33:42
description
ABC transporter for the siderophores Fe-enterobactin and Fe-bacillibactin (binding protein), with YusV as ATPase
[SW|ABC transporter] for the siderophores Fe-enterobactin and Fe-bacillibactin (binding protein), with [[protein|YusV]] as ATPase
locus
BSU01630
BSU_01630
function
acquisition of iron
[SW|acquisition of iron]
product
ABC transporter for the siderophores Fe-enterobactin
and Fe-bacillibactin (binding protein)
[SW|ABC transporter] for the siderophores Fe-enterobactin and Fe-bacillibactin (binding protein) [pubmed|28283524]
ec
outlinks
bsu
BSU01630
BSU_01630
[SW|Categories] containing this gene/protein
[SW|ABC transporters], [SW|acquisition of iron], [SW|iron metabolism], [SW|membrane proteins]
The protein
Protein family
Fe/B12 periplasmic-binding domain (according to Swiss-Prot)
[SW|Bacterial solute-binding protein 8 family] (according to UniProt)
The protein
[SW|Domains]
Two independent non-symmetric globular domains, connected by a long alpha-helix (residues 143-164 of the mature protein).
Two independent non-symmetric globular domains, connected by a long alpha-helix (residues 143-164 of the mature protein).
[SW|Fe/B12 periplasmic-binding domain] (aa 57-317) (according to UniProt)
The protein
Structure
[PDB|2PHZ], [PDB|2WI8], [PDB|2WHY] (complex with ferri-bacillibactin), [PDB|2XUZ] (complex with ferri-enterobactin), [PDB|2XV1] (complex with ferric mecam)
[PDB|2PHZ], [PDB|2WI8], [PDB|2WHY] (complex with ferri-bacillibactin)
[PDB|2XUZ] (complex with ferri-enterobactin)
[PDB|2XV1] (complex with ferric mecam)
The protein
[SW|Interactions]
[[protein|YusV]]-([[protein|FeuB]]-[[protein|FeuC]])-[[protein|FeuA]] [Pubmed|10092453]
Expression and Regulation
Operon
''[[protein|feuA]]-[[protein|feuB]]-[[protein|feuC]]-[[protein|ybbA]]'' [Pubmed|12354229]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigA]] [Pubmed|17725565]
Expression and Regulation
Regulation
repressed in the presence of iron ([[protein|Fur]], [[protein|CitB]]) [Pubmed|12354229]
induced in the presence of iron chelators bacillibactin or enterobactin ([[protein|Btr]]) [Pubmed|17725565]
Expression and Regulation
Regulatory mechanism
[[protein|Fur]]: transcription repression [Pubmed|12354229]
[[protein|CitB]]: binding to the iron responsive element in the absence of iron
[[protein|Btr]]: transcription activation in the presence of the co-activators bacillibactin or enterobactin [Pubmed|17725565]
References
proteinLength
317
geneLength
954
Gene
Coordinates
182,370 183,323
The protein
Paralogous protein(s)
[[this]]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
BKE01630 ([[gene|feuA]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE01630 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTATAGAGCCTCCTGTT, downstream forward: _UP4_AACTAATTCAGAGTAGGTTT
BKK01630 ([[gene|feuA]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK01630 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTATAGAGCCTCCTGTT, downstream forward: _UP4_AACTAATTCAGAGTAGGTTT
Biological materials
two-hybrid system
''B. pertussis'' adenylate cyclase-based bacterial two hybrid system ([SW|BACTH]), available in [SW|Jörg Stülke]'s lab