SubtiBank SubtiBank
Version comparison:

2019-08-09 07:48:292025-05-12 05:30:46

The protein

Catalyzed reaction/ biological activity

removal of pyrophosphate from the 5' end of mRNAs to make RNA accessible for degradation by [SW|RNases] [Pubmed|21925382]

RppH requires at least two unpaired nucleotides at the 5' end of its RNA substrates and prefers three or more. The second of these 5'-terminal nucleotides must be G, whereas a less strict preference for a purine is evident at the third position, and A is slightly favored over G at the first position [Pubmed|23610425,23610407]

decapping of NAD-capped RNAs [pubmed|30110644]

removal of pyrophosphate from the 5' end of mRNAs to make RNA accessible for degradation by [SW|RNases] [Pubmed|21925382]

RppH requires at least two unpaired nucleotides at the 5' end of its RNA substrates and prefers three or more. The second of these 5'-terminal nucleotides must be G, whereas a less strict preference for a purine is evident at the third position, and A is slightly favored over G at the first position [Pubmed|23610425,23610407]

decapping of NAD-capped RNAs [pubmed|30110644]

8-oxo-dGTP + H2O --> 8-oxo-dGMP + diphosphate + H+ (according to UniProt)

References

Reviews

22568516

22568516, 32061882

The protein

[SW|Domains]

[SW|Nudix hydrolase domain] (aa 6-145) (according to UniProt)