SubtiBank SubtiBank
Version comparison:

Tue Dec 13 2016 11:16:35 GMT+0100 (CET)2025-05-12 09:48:48

description

cysteine desulfurase, sulfur transfer to TrmU, involved in 2-thiouridine (s2U) modification of the wobble position in glutamate, glutamine and lysine tRNA molecules

cysteine desulfurase, sulfur transfer to [[protein|TrmU]], involved in 2-thiouridine (s2U) modification of the wobble position in glutamate, glutamine and lysine tRNA molecules

locus

BSU27510

BSU_27510

names

yrvO

nifS

iscS

yrvO

nifS

iscS

iscS1

outlinks

bsu

BSU27510

BSU_27510

aminos

MERIYLDHAATSPMDERVLEQMIPHFSGSFGNPSSIHSFGRESRKWVDEARAQIAAEIGAAEQEIIFTSGGTEADNLAIMGTALARKDLGRHIITTKIEHHAVLHTCEKLEGDGFDITYLDVDQNGRVSAKQVKEALRDDTILVTVMYGNNEVGTVQPIEEIGELLKEHKAYFHTDAVQAFGLLPIDVKNSHIDLLSVSGHKLNGPKGTGFLYASKDVKLSPLLFGGEQERKRRAGTENVPGIVGLKEAIKLSSEERDEKNEKYQSFKAIFADTLRDAGVAFEVNGDKEHSLPHVLNLYFPGVSVEALLVNLDMAGVAVSSGSACTAGSVLPSHVLTAMFGEESDRLTSSIRISFGLGNTAEQVKTAAKHVADVVKRLT

[SW|Categories] containing this gene/protein

[SW|essential genes], [SW|translation], [SW|phosphoproteins]

Gene

Coordinates on the chromosome (coding sequence)

2,810,559 -> 2,811,698

The protein

Catalyzed reaction/ biological activity

2-thiouridine (s2U) modification of the wobble position in glutamate, glutamine and lysine tRNA molecules (together with [[protein|TrmU]]) [Pubmed|25825430]

2-thiouridine (s2U) modification of the wobble position in glutamate, glutamine and lysine tRNA molecules (together with [[protein|TrmU]]) [Pubmed|25825430]

[sulfur carrier]-H + L-cysteine --> [sulfur carrier]-SH + L-alanine (according to UniProt)

The protein

Paralogous protein(s)

[[protein|NifS]], [[protein|NifZ]], [[protein|SufS]], [[protein|YcbU]]

[[this]]

The protein

[SW|Interactions]

[[protein|YrvO]]-[[protein|TrmU]] [Pubmed|25825430]

Expression and Regulation

Operon

''[[protein|cymR]]-[[protein|yrvO]]-[[protein|trmU]]'' [Pubmed|16885442]

Expression and Regulation

[SW|Sigma factor]

[[protein|SigA]] [Pubmed|16885442]

Expression and Regulation

Regulation

[[protein|RelA]] dependent downregulation (Class I) during stringent response [Pubmed|11948165]

proteinLength

379

geneLength

1140

Gene

Coordinates

2,810,559 2,811,698

The protein

Protein family

[SW|Class-V pyridoxal-phosphate-dependent aminotransferase family] (according to UniProt)

The protein

[SW|Cofactors]

PLP

Expression and Regulation

Operons

[[this]]

Expression and Regulation

Other regulations

[[this]]

Biological materials

Mutant

MGNA-A828 (yrvO::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/828 NBRP B. subtilis, Japan]