Tue Dec 13 2016 11:16:35 GMT+0100 (CET)2025-05-12 09:48:48
description
cysteine desulfurase, sulfur transfer to TrmU, involved in 2-thiouridine (s2U) modification of the wobble position in glutamate, glutamine and lysine tRNA molecules
cysteine desulfurase, sulfur transfer to [[protein|TrmU]], involved in 2-thiouridine (s2U) modification of the wobble position in glutamate, glutamine and lysine tRNA molecules
locus
BSU27510
BSU_27510
names
yrvO
nifS
iscS
yrvO
nifS
iscS
iscS1
outlinks
bsu
BSU27510
BSU_27510
aminos
MERIYLDHAATSPMDERVLEQMIPHFSGSFGNPSSIHSFGRESRKWVDEARAQIAAEIGAAEQEIIFTSGGTEADNLAIMGTALARKDLGRHIITTKIEHHAVLHTCEKLEGDGFDITYLDVDQNGRVSAKQVKEALRDDTILVTVMYGNNEVGTVQPIEEIGELLKEHKAYFHTDAVQAFGLLPIDVKNSHIDLLSVSGHKLNGPKGTGFLYASKDVKLSPLLFGGEQERKRRAGTENVPGIVGLKEAIKLSSEERDEKNEKYQSFKAIFADTLRDAGVAFEVNGDKEHSLPHVLNLYFPGVSVEALLVNLDMAGVAVSSGSACTAGSVLPSHVLTAMFGEESDRLTSSIRISFGLGNTAEQVKTAAKHVADVVKRLT
[SW|Categories] containing this gene/protein
[SW|essential genes], [SW|translation], [SW|phosphoproteins]
Gene
Coordinates on the chromosome (coding sequence)
2,810,559 -> 2,811,698
The protein
Catalyzed reaction/ biological activity
2-thiouridine (s2U) modification of the wobble position in glutamate, glutamine and lysine tRNA molecules (together with [[protein|TrmU]]) [Pubmed|25825430]
2-thiouridine (s2U) modification of the wobble position in glutamate, glutamine and lysine tRNA molecules (together with [[protein|TrmU]]) [Pubmed|25825430]
[sulfur carrier]-H + L-cysteine --> [sulfur carrier]-SH + L-alanine (according to UniProt)
The protein
Paralogous protein(s)
[[protein|NifS]], [[protein|NifZ]], [[protein|SufS]], [[protein|YcbU]]
[[this]]
The protein
[SW|Interactions]
[[protein|YrvO]]-[[protein|TrmU]] [Pubmed|25825430]
Expression and Regulation
Operon
''[[protein|cymR]]-[[protein|yrvO]]-[[protein|trmU]]'' [Pubmed|16885442]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigA]] [Pubmed|16885442]
Expression and Regulation
Regulation
[[protein|RelA]] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
proteinLength
379
geneLength
1140
Gene
Coordinates
2,810,559 2,811,698
The protein
Protein family
[SW|Class-V pyridoxal-phosphate-dependent aminotransferase family] (according to UniProt)
The protein
[SW|Cofactors]
PLP
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
MGNA-A828 (yrvO::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/828 NBRP B. subtilis, Japan]