Sat May 21 2016 12:50:17 GMT+0200 (CEST)2025-06-01 07:44:02
locus
BSU32000
BSU_32000
outlinks
bsu
BSU32000
BSU_32000
[SW|Categories] containing this gene/protein
[SW|acquisition of iron], [SW|iron metabolism]
Gene
Coordinates on the chromosome (coding sequence)
3,291,511 -> 3,292,296
The protein
Catalyzed reaction/ biological activity
2,3-dihydro-2,3-dihydroxybenzoate
(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD+ --> 2,3-dihydroxybenzoate + H+ + NADH (according to UniProt)
The protein
Protein family
short-chain dehydrogenases/reductases (SDR) family (according to Swiss-Prot)
[SW|Short-chain dehydrogenases/reductases (SDR) family] (according to UniProt)
Expression and Regulation
Operon
''[[protein|dhbA]]-[[protein|dhbC]]-[[protein|dhbE]]-[[protein|dhbB]]-[[protein|dhbF]]'' [Pubmed|8921902]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigA]] [Pubmed|8550523]
Expression and Regulation
Regulation
induced by iron starvation ([[protein|Fur]]) [Pubmed|12354229]
Expression and Regulation
Regulatory mechanism
[[protein|Fur]]: transcription repression [Pubmed|12354229]
[[protein|AbrB]]: transcription repression [Pubmed|20817675]
Expression and Regulation
Additional information
the ''[[protein|dhbA]]-[[protein|dhbC]]-[[protein|dhbE]]-[[protein|dhbB]]-[[protein|dhbF]]'' operon is strongly unregulated in a ''[SW|kre]'' mutant [Pubmed|26110430]
References
proteinLength
261
geneLength
786
Gene
Coordinates
3,291,511 3,292,296
Gene
Phenotypes of a mutant
defective in biofilm formation, this can be suppressed by the addition of 2,3-dihydroxybenzoate to the medium [pubmed|31420537]
The protein
Paralogous protein(s)
[[this]]
The protein
Structure
[PDB|2FWM] (from E. coli, 42% identity) [pubmed|16790929]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
BKE32000 ([[gene|dhbA]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE32000 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATCATCAATTCCTTTCT, downstream forward: _UP4_TAACTGAATTTAAAGGAGGT
BKK32000 ([[gene|dhbA]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK32000 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATCATCAATTCCTTTCT, downstream forward: _UP4_TAACTGAATTTAAAGGAGGT